Cochlin Protein (COCH Protein)

Coagulation factor C homolog, cochlin

Cochlin Products

Cochlin Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat No
Cochlin	Human	Cochlin/COCH Protein, Recombinant	11368-H07H
Cochlin	Human	Cochlin/COCH (isoform short) , Recombinant Protein	11368-H07HS

Cochlin cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat No
Cochlin	Human	Homo sapiens Cochlin/COCH cDNA Clone	HG11368-M

Cochlin Related Areas

Immunology>>Adhesion Molecule>>Extracellular Matrix Molecule>>Extracellular Matrix Protein>>Cochlin

Cochlin Alternative Names

Cochlin, COCH, UNQ257/PRO294, COCH-5B2, COCH5B2, DFNA9 [Homo sapiens]

Cochlin, Coch, AW122937, Coch-5B2, D12H14S564E [Mus musculus]

Cochlin Background

Cochlin, also known as COCH-5B2 and COCH, is a secreted protein which contains one LCCL domain and two VWFA domains. It is an abundant inner ear protein expressed as multiple isoforms. Its function is also unknown, but it is suspected to be an extracellular matrix component. Cochlin and type II collagen are major constituents of the inner ear extracellular matrix, and Cochlin constitutes 70% of non-collagenous protein in the inner ear, the cochlin isoforms can be classified into three subgroups, p63s, p44s and p40s. The expression of cochlin is highly specific to the inner ear. Eleven missense mutation and one in-frame deletion have been reported in the COCH gene, causing hereditary progressive sensorineural hearing loss and vestibular dysfunction, deafness autosomal dominant type 9 (DFNA9). The co-localization of cochlin and type II collagen in the fibrillar substance in the subepithelial area indicate that cochlin may play a role in the structural homeostasis of the vestibule acting in concert with the fibrillar type II collagen bundles. Defects in COCH may contribute to Meniere disease which is an autosomal dominant disorder characterized by hearing loss associated with episodic vertigo.

Cochlin Related Studies

1. Ikezono T, et al. (2005) Expression of cochlin in the vestibular organ of rats. ORL J Otorhinolaryngol Relat Spec. 67(5): 252-8.
2. Shindo S, et al. (2008) Spatiotemporal expression of cochlin in the inner ear of rats during postnatal development. Neurosci Lett. 444(2): 148-52.
3. Hosokawa S, et al. (2010) Ultrastructural localization of cochlin in the rat cochlear duct. Audiol Neurootol. 15(4): 247-53.