Coagulative Disorders Therapeutic Targets

Protein Name	Alternative Names	BioChemical Class / Role	Products (Cat NO)
			Protein	Antibody	Gene cDNA clones
TPSB2	TPS2, tryptaseB, tryptaseC	It comprise a family of trypsin-like serine proteases, the peptidase family S1, and fall into two groups, α and β. Tryptase is unique in two respects: it is enzymatically active only as a heparin-stabilized tetramer, and it is resistant to all known endogenous proteinase inhibitors because of the unique arrangement of the active sites.	10505-H08H		HG10505-M
Coagulation Factor X	F10,RP11-98F14.9, FX, FXA	It is an enzyme of the coagulation cascade. Apart from congenital deficiency, low factor X levels may occur occasionally in a number of disease states. Furhermore, factor X deficiency may be seen in amyloidosis, where factor X is adsorbed to the amyloid fibrils in the vasculature.	11076-H08B		HG11076-M
PAI-1/SerpinE1	PAI, PAI1, PLANH1	It is a secreted protein which belongs to the serpin family. SERPINE1 acts as 'bait' for tissue plasminogen activator, urokinase, and protein C. Its rapid interaction with TPA may function as a major control point in the regulation of fibrinolysis.	10296-H08H		HG10296-M
Coagulation factor VII	FVII, F7	It is a member of the peptidase S1 family, and is one of the central proteins in the coagulation cascade. The main role of factor VII is to initiate the process of coagulation in conjunction with tissue factor (TF).	50034-M08C		HG11506-M, MG50034-M