Anti-Factor XI Antibody

Cat: 10302-MM04
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Anti-Factor XI Antibody (Mouse Monoclonal antibody) General Information
Product name
Anti-Factor XI Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human Factor XI
No cross-reactivity in ELISA with Human uPA / PLAU Human Kallikrein-11 / KLK-11 Human Kallikrein-1 / KLK-1 Human HGFA / HGF Activator
Immunogen
Recombinant Human FXI protein (Catalog#10302-H08H)
Preparation
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Factor XI (rh Factor XI; Catalog#10302-H08H; NP_000119.1; Met 1-Val 625). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Source
Monoclonal Mouse IgG1 Clone #2B7E12F8
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-Factor XI Antibody (Mouse Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-Factor XI Antibody Alternative Names
Anti-coagulation factor 11 Antibody;Anti-coagulation factor XI Antibody;Anti-FXI Antibody
Factor XI Background Information

Factor XI (plasma thromboplastin antecedent) is a plasma glycoprotein, and a zymogen acting as a serine protease which participates in blood coagulation as a catalyst in the conversion of factor IX to factor IXa in the presence of calcium ions. It is an unusual dimeric protease, with structural features that distinguish it from vitamin K-dependent coagulation proteases. The factor XI is synthesized in the liver as a single polypeptide chain with a molecular weight estimated between 125 ~160 kDa and then is processed into a disulfide-bond linked homodimer. FXI is a homodimer, with each subunit containing four apple domains and a protease domain. The apple domains form a disk structure with binding sites for platelets, high molecular weight kininogen, and the substrate factor IX (FIX). FXI is converted to the active protease FXIa by cleavage of the Arg369-Ile370 bond on each subunit. After the activation reaction, Factor XIa is composed of two heavy and two light chains held together by three disulfide bonds. The heavy chains are derived from the amino termini of the zymogen and responsible for the binding of factor XI to high molecular weight kininogen and for the activation of factor IX, while the light chain contains the catalytic portion of the enzyme and is homologous to the trypsin family of serine proteases. FXI deficiency is a disorder characterized by a mild or no bleeding tendency. Severe FXI deficiency is an injury-related bleeding disorder common in Ashkenazi Jews and rare worldwide.

Full Name
coagulation factor XI
References
  • Gailani D, et al. (2009) Structural and functional features of factor XI. J Thromb Haemost. 7 Suppl 1: 75-8.
  • Duga S, et al. (2009) Factor XI Deficiency. Semin Thromb Hemost. 35(4): 416-25.
  • Emsley J, et al. (2010) Structure and function of factor XI. Blood. 115(13): 2569-77.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-Factor XI Antibody Rabbit Polyclonal ELISA 10302-RP02
    Anti-Factor XI Antibody Rabbit Monoclonal ELISA 10302-R006
    Anti-Factor XI Antibody Rabbit Polyclonal ELISA 10302-RP01
    Anti-Factor XI Antibody Rabbit Polyclonal ELISA,IHC-P 10302-T24
    Anti-Factor XI Antibody Rabbit Monoclonal ELISA 10302-R007
    Anti-Factor XI Antibody Rabbit Polyclonal ELISA 10302-T16
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