Anti-Factor VIII Antibody (Rabbit Monoclonal antibody) General Information
Anti-Factor VIII Antibody
Reacts with: Human
Human Factor VIII
Recombinant Human Coagulation Factor VIII / FVIII / F8 protein
This antibody was obtained from a rabbit immunized with purified, recombinant Human Coagulation Factor VIII / FVIII / F8 protein.
Monoclonal Rabbit IgG Clone #226
0.2 μm filtered solution in PBS
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-Factor VIII Antibody (Rabbit Monoclonal antibody) Validated Applications
**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********
Anti-Factor VIII Antibody Alternative Names
Anti-AHF Antibody;Anti-Coagulation Factor 8 Antibody;Anti-Coagulation Factor VIII Antibody;Anti-DXS1253E Antibody;Anti-F8B Antibody;Anti-F8C Antibody;Anti-FVIII Antibody;Anti-HEMA Antibody
Factor VIII Background Information
Coagulation Factor VIII, also known as FVIII and F8, is a member of the multicopper oxidase family. Coagulation Factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. It contains 3 F5/8 type A domains, 2 F5/8 type C domains and 6 plastocyanin-like domains. FVIII is synthesized in the liver, and perhaps in other tissues. It is a coagulation cofactor which circulates bound to von Willebrand factor and is part of the intrinsic coagulation pathway. It is a macromolecular complex composed of two separate entities, one of which, when deficient, results in hemophilia A, and the other, when deficient, results in von Willebrand's disease. Hemophilia A is a disorder of blood coagulation characterized by a permanent tendency to hemorrhage. About 50% of patients have severe hemophilia resulting in frequent spontaneous bleeding into joints, muscles and internal organs. Less severe forms are characterized by bleeding after trauma or surgery.
coagulation factor VIII, procoagulant component
Toole JJ. et al., 1984, Nature. 312(5992): 342-7.Truett MA. et al., 1985, DNA. 4(5): 333-49.Antonarakis SE. et al., 1995, Haemost. 74(1): 322-8.