Quick Order

Coagulation Factor VIII / FVIII / F8 Antibody (Heavy Chain), Rabbit MAb

    DatasheetReviewsRelated ProductsProtocols
    Human F8 Antibody Product Information
    Immunogen:Recombinant Human Coagulation Factor VIII / FVIII / F8 protein
    Clone ID:226
    Ig Type:Rabbit IgG
    Concentration:
    Formulation:0.2 μm filtered solution in PBS
    Preparation:This antibody was obtained from a rabbit immunized with purified, recombinant Human Coagulation Factor VIII / FVIII / F8 protein.
    Other F8 Antibody Products

    Anti-Histone H3 rabbit monoclonal antibody at 1:200 dilution

    Lane A: NIH3T3 Whole Cell Lysate

    Lane B: Hela Whole Cell Lysate

    Lysates/proteins at 30 μg per lane.

    Secondary

    Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution.

    Developed using the ECL technique.

    Performed under reducing conditions.

    Predicted band size:15 kDa

    Observed band size:17 kDa

    Coagulation Factor VIII / FVIII / F8 Background

    Coagulation Factor VIII, also known as FVIII and F8, is a member of the multicopper oxidase family. Coagulation Factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. It contains 3 F5/8 type A domains, 2 F5/8 type C domains and 6 plastocyanin-like domains. FVIII is synthesized in the liver, and perhaps in other tissues. It is a coagulation cofactor which circulates bound to von Willebrand factor and is part of the intrinsic coagulation pathway. It is a macromolecular complex composed of two separate entities, one of which, when deficient, results in hemophilia A, and the other, when deficient, results in von Willebrand's disease. Hemophilia A is a disorder of blood coagulation characterized by a permanent tendency to hemorrhage. About 50% of patients have severe hemophilia resulting in frequent spontaneous bleeding into joints, muscles and internal organs. Less severe forms are characterized by bleeding after trauma or surgery.

    Human Coagulation Factor VIII / FVIII / F8 References
  • Toole JJ. et al., 1984, Nature. 312(5992): 342-7.
  • Truett MA. et al., 1985, DNA. 4(5): 333-49.
  • Antonarakis SE. et al., 1995, Haemost. 74(1): 322-8.
  • Product nameProduct name
    Size / Price
    Catalog: 13909-R226-50
    List Price: 
    Price:      (You Save: )
    Size:
    50 µg
    100 µg
    Quantity:+-
    AvailabilityIn Stock
    Add to CartBulk Discount Inquiry

    Datasheet & Documentation

    All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"