>Rabbit MAb Antibody
>Coagulation Factor VIII / FVIII / F8 (Heavy Chain) Antibody
|Catalog||Size (Price)||Quantity||In Stock||Operation||Other Information|
Coagulation Factor VIII / FVIII / F8 Antibody Datasheet
|Order or Inquire for Coagulation Factor VIII / FVIII / F8 Antibody product||Quality antibodies||Antibody production services|
|Detection limit is 0.078 ng/well in ELISA|
Coagulation Factor VIII / FVIII / F8 Antibody Product Information
Recombinant Human Coagulation Factor VIII / FVIII / F8 protein
|Antibody Type :||Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )|
Clone ID :
|Ig Type :||
|Formulation :||0.2 μm filtered solution in PBS with 5% trehalose|
This antibody was obtained from a rabbit immunized with purified, recombinant Human Coagulation Factor VIII / FVIII / F8 protein.
Coagulation Factor VIII / FVIII / F8 Antibody Usage Guide
Human Coagulation Factor VIII / FVIII / F8 Heavy Chain
|Western blot :||This antibody can be used at 1-2 μg/mL with the appropriate secondary reagents to detect Human FⅧ in WB.|
|Direct ELISA :||This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human FⅧ. The detection limit for Human FⅧ is approximately 0.078ng/well.|
|Storage :||This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Coagulation Factor VIII / FVIII / F8 Antibody Related Products & Topics
Coagulation Factor VIII / FVIII / F8 Antibody Background
Coagulation Factor VIII, also known as FVIII and F8, is a member of the multicopper oxidase family. Coagulation Factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. It contains 3 F5/8 type A domains, 2 F5/8 type C domains and 6 plastocyanin-like domains. FVIII is synthesized in the liver, and perhaps in other tissues. It is a coagulation cofactor which circulates bound to von Willebrand factor and is part of the intrinsic coagulation pathway. It is a macromolecular complex composed of two separate entities, one of which, when deficient, results in hemophilia A, and the other, when deficient, results in von Willebrand's disease. Hemophilia A is a disorder of blood coagulation characterized by a permanent tendency to hemorrhage. About 50% of patients have severe hemophilia resulting in frequent spontaneous bleeding into joints, muscles and internal organs. Less severe forms are characterized by bleeding after trauma or surgery.
- Toole JJ. et al., 1984, Nature. 312(5992): 342-7.
- Truett MA. et al., 1985, DNA. 4(5): 333-49.
- Antonarakis SE. et al., 1995, Haemost. 74(1): 322-8.