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Coagulation Factor VII Protein & Antibody (FVII, F7)

Coagulation Factor VII Protein Products

Coagulation Factor VII Protein, Recombinant

Molecule Species Description //For Detailed Info. and Price------CLICK! Cat. No
Coagulation Factor VII Human Coagulation Factor VII/FVII/F7 Protein, Recombinant 11506-H08H
Coagulation Factor VII Mouse Coagulation Factor VII/FVII/F7 Protein, Recombinant 50034-M08C
Coagulation Factor VII Mouse FVII / Factor VII / F7 Protein, Recombinant 50034-M08S

  50034-M08C: The specific activity is > 4 pmoles / min / µg. Measured by its ability to cleave the fluorogenic peptide substrate Boc-VPR-AMC (R&D Systems, Catalog # ES011).

Coagulation Factor VII Antibody

Molecule Application Description //For Detailed Info. and Price------CLICK! Cat. No
Mouse
Coagulation Factor VII
WB, ELISA Coagulation Factor VII Antibody, Rabbit MAb 50034-R121
Mouse
Coagulation Factor VII
WB, ELISA Rabbit Polyclonal Antibody 50034-RP01
Mouse
Coagulation Factor VII
WB, ELISA Rabbit Polyclonal Antibody (Antigen Affinity Purified) 50034-RP02

Coagulation Factor VII cDNA Clone

Molecule Species Description //For Detailed Info. and Price------CLICK! Cat. No
Coagulation Factor VII Human Homo sapiens Coagulation Factor VII/FVII/F7 cDNA Clone HG11506-M
Coagulation Factor VII Mouse Mus musculus Coagulation Factor VII/FVII/F7 cDNA Clone MG50034-M

Coagulation Factor VII Related Areas

Enzyme>>Protease & Regulator>>Serine Protease & Regulator>>Coagulation Factor VII

Immunology>>Innate Immunity>>Coagulation>>Coagulation Factor VII

Cardiovascular>>Coagulation>>Coagulation Factor VII

Coagulation Factor VII Alternative Names

Coagulation Factor VII, FVII, F7 [Homo sapiens]

Coagulation Factor VII, FVII, F7, AI132620, Cf7, mfVII [Mus musculus]

Coagulation Factor VII Background

Coagulation factor VII, also known as Serum prothrombin conversion accelerator, Factor VII, F7 and FVII, is a member of the peptidase S1 family. Factor VII is one of the central proteins in the coagulation cascade. It is an enzyme of the serine protease class, and Factor VII (FVII) deficiency is the most frequent among rare congenital bleeding disorders. Factor VII contains two EGF-like domains, one Gla (gamma-carboxy-glutamate) domain and one peptidase S1 domain. The main role of factor VII is to initiate the process of coagulation in conjunction with tissue factor (TF). Tissue factor is found on the outside of blood vessels, normally not exposed to the blood stream. The action of the Factor VII is impeded by tissue factor pathway inhibitor (TFPI), which is released almost immediately after initiation of coagulation. Factor VII is vitamin K dependent and is produced in the liver. The use of warfarin or similar anticoagulants impairs its function. Upon vessel injury, tissue factor is exposed to the blood and circulating Factor VII. Once bound to TF, FVII is activated to FVIIa by different proteases, among which are thrombin (factor IIa), factor Xa, IXa, XIIa, and the FVIIa-TF complex itself. Recombinant activated factor VII (rFVIIa) is a haemostatic agent, which was originally developed for the treatment of haemophilia patients with inhibitors against factor FVIII or FIX. FVIIa binds specifically to endothelial protein C receptor (EPCR), a known cellular receptor for protein C and activated protein C, on the endothelium. rFVIIa is a novel hemostatic agent, originally developed for the treatment of hemorrhage in hemophiliacs with inhibitors, which has been successfully used recently in an increasing number of nonhemophilic bleeding conditions.

Coagulation Factor VII Related Studies

  1. Franchini M, et al. (2007) Potential role of recombinant activated factor VII for the treatment of severe bleeding associated with disseminated intravascular coagulation: a systematic review. Blood Coagul Fibrinolysis. 18(7): 589-93.
  2. Lapecorella M, et al. (2008) Factor VII deficiency: defining the clinical picture and optimizing therapeutic options. Haemophilia. 14(6): 1170-5.
  3. Grottke O, et al. (2010) Activated recombinant factor VII (rFVIIa). Best Pract Res Clin Anaesthesiol. 24(1): 95-106.

 

 

Coagulation Factor VII related areas, pathways, and other information

 

 

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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