Anti-Factor VII Antibody

Cat: 50034-R121
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Anti-Factor VII Antibody (Rabbit Monoclonal antibody) General Information
Product name
Anti-Factor VII Antibody
Validated applications
ELISA,ELISA(Det)
Species reactivity
Reacts with: Mouse
Specificity
Mouse Factor VII
No cross-reactivity in ELISA with Human F10 / FX / Factor X Human F11 / FXI / Factor XI Human Kallikrein-1 / KLK-1 Human Kallikrein-13 / KLK-13 Human Kallikrein-11 / KLK-11 Human Kallikrein-7 / KLK-7
Immunogen
Recombinant Mouse FVII protein (Catalog#50034-M08C)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse FVII (rM FVII; Catalog#50034-M08C; NP_034302.2; Met 1-Leu 446).
Source
Monoclonal Rabbit IgG Clone #121
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-Factor VII Antibody (Rabbit Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  
ELISA(Det) 1:1000-1:10000 This antibody will detect Mouse Coagulation Factor VII in ELISA pair set (Catalog: # SEK50034). In a sandwich ELISA, it can be used as detection antibody when paired with (Catalog: # 50034-R003).

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-Factor VII Antibody Alternative Names
Anti-AI132620 Antibody;Anti-Cf7 Antibody;Anti-FVII Antibody
Factor VII Background Information

Coagulation factor VII, also known as Serum prothrombin conversion accelerator, Factor VII, F7 and FVII, is a member of the peptidase S1 family. Factor VII is one of the central proteins in the coagulation cascade. It is an enzyme of the serine protease class, and Factor VII (FVII) deficiency is the most frequent among rare congenital bleeding disorders. Factor VII contains two EGF-like domains, one Gla (gamma-carboxy-glutamate) domain and one peptidase S1 domain. The main role of factor VII is to initiate the process of coagulation in conjunction with tissue factor (TF). Tissue factor is found on the outside of blood vessels, normally not exposed to the blood stream. The action of the Factor VII is impeded by tissue factor pathway inhibitor (TFPI), which is released almost immediately after initiation of coagulation. Factor VII is vitamin K dependent and is produced in the liver. Upon vessel injury, tissue factor is exposed to the blood and circulating Factor VII. Once bound to TF, FVII is activated to FVIIa by different proteases, among which are thrombin (factor IIa), factor Xa, IXa, XIIa, and the FVIIa-TF complex itself. Recombinant activated factor VII (rFVIIa) is a haemostatic agent, which was originally developed for the treatment of haemophilia patients with inhibitors against factor FVIII or FIX. FVIIa binds specifically to endothelial protein C receptor (EPCR), a known cellular receptor for protein C and activated protein C, on the endothelium. rFVIIa is a novel hemostatic agent, originally developed for the treatment of hemorrhage in hemophiliacs with inhibitors, which has been successfully used recently in an increasing number of nonhemophilic bleeding conditions.

Full Name
coagulation factor VII (serum prothrombin conversion accelerator)
References
  • Franchini M, et al. (2007) Potential role of recombinant activated factor VII for the treatment of severe bleeding associated with disseminated intravascular coagulation: a systematic review. Blood Coagul Fibrinolysis. 18(7): 589-93.
  • Lapecorella M, et al. (2008) Factor VII deficiency: defining the clinical picture and optimizing therapeutic options. Haemophilia. 14(6): 1170-5.
  • Grottke O, et al. (2010) Activated recombinant factor VII (rFVIIa). Best Pract Res Clin Anaesthesiol. 24(1): 95-106.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-Factor VII Antibody Rabbit Polyclonal ELISA 50034-RP01
    Anti-Factor VII Antibody Rabbit Polyclonal ELISA 50034-RP02
    Anti-Factor VII Antibody Rabbit Monoclonal ELISA(Cap) 50034-R003
    Anti-Factor VII Antibody Rabbit Monoclonal ELISA 50034-R279
    info info
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