All Tissue Factor reagents are produced in house and quality controlled, including 15 Tissue Factor Antibody, 1 Tissue Factor ELISA, 53 Tissue Factor Gene, 1 Tissue Factor IPKit, 7 Tissue Factor Lysate, 8 Tissue Factor Protein, 3 Tissue Factor qPCR. All Tissue Factor reagents are ready to use.
Recombinant Tissue Factor proteins are expressed by HEK293 Cells, Yeast, Baculovirus-Insect Cells with fusion tags as C-His, C-human IgG1-Fc.
Tissue Factorantibodies are validated with different applications, which are ELISA, FCM, WB, IP, ELISA(Cap), ICC/IF, IF.
Tissue FactorcDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each Tissue Factor of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
Tissue FactorELISA Kit are quality controlled by 8 internation QC standard which guarantee every ELISA Kit with high quality.
Expression host: Baculovirus-Insect Cells
Tissue factor (TF), also known as coagulation factor III, F3, and CD142, is a single-pass type I membrane protein which belongs to the tissue factor family. Tissue factor is one of the proteins that participate in hemostatic and inflammatory processes. Activated monocytes present in the liver increase expression of tissue factor, and while accumulating in the organ they can intensify inflammation. Tissue factor is the protein that activates the blood clotting system by binding to, and activating, the plasma serine protease, factor VIIa, following vascular injury. Tissue factor is not only the main physiological initiator of normal blood coagulation, but is also important in the natural history of solid malignancies in that it potentiates metastasis and angiogenesis and mediates outside-in signalling. Tissue factor is expressed constitutively by many tissues which are not in contact with blood and by other cells upon injury or activation; the latter include endothelial cells, tissue macrophages, and peripheral blood monocytes. Coagulation Factor III is a transmembrane glycoprotein that localizes the coagulation serine protease factor VII/VIIa (FVII/VIIa) to the cell surface. The primary function of TF is to activate the clotting cascade. The TF:FVIIa complex also activates cells by cleavage of a G-protein coupled receptor called protease-activated receptor 2 (PAR2). TF is expressed by tumor cells and contributes to a variety of pathologic processes, such as thrombosis, metastasis, tumor growth, and tumor angiogenesis. As a key regulator of haemostasis and angiogenesis, it is also involved in the pathology of several diseases, including cardiovascular, inflammatory and neoplastic conditions.