Coagulation Factor III / Tissue Factor Protein & Antibody (CD142, TF)

Cluster of Differentiation 142

Coagulation Factor III / Tissue Factor Products

Coagulation Factor III / Tissue Factor Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
Coagulation Factor III/Tissue Factor	Human	F3 / Tissue factor / CD142 Protein, Recombinant	13133-H08H
Coagulation Factor III/Tissue Factor	Human	F3 / Tissue factor / CD142 Protein, Recombinant	13133-H02H
Coagulation Factor III/Tissue Factor	Mouse	Coagulation Factor III / F3 / Tissue Factor / CD142 Protein, Recombinant	50413-M08H
Coagulation Factor III/Tissue Factor	Rat	F3 / Tissue factor / CD142 Protein, Recombinant	80407-R08H

  50413-M08H: The AC₅₀ is < 5 µg/mL. Measured by its ability to activate Coagulation Factor VII in cleaving a fluorogenic peptide substrate Boc-VPR-AMC (R&D Systems, Catalog# ES011).

Coagulation Factor III / Tissue Factor Antibody

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human Coagulation Factor III/Tissue Factor	ELISA	F3 / Tissue factor / CD142 Antibody	13133-MM05
Human Coagulation Factor III/Tissue Factor	FCM	F3 / Tissue factor / CD142 Antibody ( FITC )	13133-MM05-F
Mouse Coagulation Factor III/Tissue Factor	WB, ELISA	Coagulation Factor III / F3 / Tissue Factor / CD142 Antibody	50413-R034
Mouse Coagulation Factor III/Tissue Factor	WB, ELISA	F3 / Tissue Factor / CD142 Rabbit PAb	50413-RP01
Mouse Coagulation Factor III/Tissue Factor	WB, ELISA	F3 / Tissue Factor / CD142 Rabbit PAb (Antigen Affinity Purified)	50413-RP02

Coagulation Factor III / Tissue Factor cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
Coagulation Factor III/Tissue Factor	Human	F3 / Tissue Factor / CD142 cDNA Clone / ORF Clone	HG13133-G
Coagulation Factor III/Tissue Factor	Mouse	Mus musculus Coagulation Factor III / F3 / Tissue Factor / CD142 cDNA Clone	MG50413-M
Coagulation Factor III/Tissue Factor	Rat	F3 / Tissue Factor / CD142 cDNA Clone / ORF Clone	RG80407-G

Coagulation Factor III / Tissue Factor Related Areas

Enzyme>>Protease & Regulator>>Serine Protease & Regulator>>Coagulation Factor III/Tissue Factor/CD142

Stem Cell>>Hematopoietic Stem Cell (HSC)>>Hemangioblast>>Endothelial Cell Marker>>Coagulation Factor III/Tissue Factor/CD142

Immunology>>Innate Immunity>>Coagulation>>Coagulation Factor III/Tissue Factor/CD142

Immunology>>Cluster of Differentiation>>Other>>Coagulation Factor III/Tissue Factor/CD142

Cardiovascular>>Coagulation>>Coagulation Factor III/Tissue Factor/CD142

Coagulation Factor III / Tissue Factor Alternative Names

Coagulation Factor III, Tissue Factor, CD142, TF, F3, TFA, thromboplastin [Homo sapiens]

Coagulation Factor III, Tissue Factor, CD142, TF, F3, Cf-3, Cf3, AA409063 [Mus musculus]

Coagulation Factor III / Tissue Factor Background

Tissue factor (TF), also known as coagulation factor III, F3, and CD142, is a single-pass type I membrane protein which belongs to the tissue factor family. Tissue factor is one of the proteins that participate in hemostatic and inflammatory processes. Activated monocytes present in the liver increase expression of tissue factor, and while accumulating in the organ they can intensify inflammation. Tissue factor is the protein that activates the blood clotting system by binding to, and activating, the plasma serine protease, factor VIIa, following vascular injury. Tissue factor is not only the main physiological initiator of normal blood coagulation, but is also important in the natural history of solid malignancies in that it potentiates metastasis and angiogenesis and mediates outside-in signalling. Tissue factor is expressed constitutively by many tissues which are not in contact with blood and by other cells upon injury or activation; the latter include endothelial cells, tissue macrophages, and peripheral blood monocytes. Coagulation Factor III is a transmembrane glycoprotein that localizes the coagulation serine protease factor VII/VIIa (FVII/VIIa) to the cell surface. The primary function of TF is to activate the clotting cascade. The TF:FVIIa complex also activates cells by cleavage of a G-protein coupled receptor called protease-activated receptor 2 (PAR2). TF is expressed by tumor cells and contributes to a variety of pathologic processes, such as thrombosis, metastasis, tumor growth, and tumor angiogenesis. As a key regulator of haemostasis and angiogenesis, it is also involved in the pathology of several diseases, including cardiovascular, inflammatory and neoplastic conditions.

Coagulation Factor III / Tissue Factor Related Studies

1. Morrissey JH. (2004) Tissue factor: a key molecule in hemostatic and nonhemostatic systems. Int J Hematol. 79(2): 103-8.
2. Milsom C, et al. (2008) Tissue factor and cancer. Pathophysiol Haemost Thromb. 36(3-4): 160-76.
3. Kasthuri RS, et al. (2009) Role of tissue factor in cancer. J Clin Oncol. 27(29): 4834-8.