Anti-Tissue Factor Antibody

Cat: 13133-T16
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Anti-Tissue Factor Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-Tissue Factor Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human Tissue Factor
Immunogen
Recombinant Human Coagulation Factor III / Tissue Factor / CD142 protein (Catalog#13133-H08H)
Preparation
Produced in rabbits immunized with purified, recombinant Human Coagulation Factor III / Tissue Factor / CD142 (rh Coagulation Factor III / Tissue Factor / CD142; Catalog#13133-H08H; P13726; Met1-Glu251). Coagulation Factor III / Tissue Factor / CD142 specific IgG was purified by Human Coagulation Factor III / Tissue Factor / CD142 affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-Tissue Factor Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 0.1-0.2 μg/mL  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-Tissue Factor Antibody Alternative Names
Anti-CD142 Antibody;Anti-coagulation factor 3 Antibody;Anti-coagulation factor III Antibody;Anti-TF Antibody;Anti-TFA Antibody
Tissue Factor Background Information

Tissue factor (TF), also known as coagulation factor III, F3, and CD142, is a single-pass type I membrane protein which belongs to the tissue factor family. Tissue factor is one of the proteins that participate in hemostatic and inflammatory processes. Activated monocytes present in the liver increase expression of tissue factor, and while accumulating in the organ they can intensify inflammation. Tissue factor is the protein that activates the blood clotting system by binding to, and activating, the plasma serine protease, factor VIIa, following vascular injury. Tissue factor is not only the main physiological initiator of normal blood coagulation, but is also important in the natural history of solid malignancies in that it potentiates metastasis and angiogenesis and mediates outside-in signalling. Tissue factor is expressed constitutively by many tissues which are not in contact with blood and by other cells upon injury or activation; the latter include endothelial cells, tissue macrophages, and peripheral blood monocytes. Coagulation Factor III is a transmembrane glycoprotein that localizes the coagulation serine protease factor VII/VIIa (FVII/VIIa) to the cell surface. The primary function of TF is to activate the clotting cascade. The TF:FVIIa complex also activates cells by cleavage of a G-protein coupled receptor called protease-activated receptor 2 (PAR2). TF is expressed by tumor cells and contributes to a variety of pathologic processes, such as thrombosis, metastasis, tumor growth, and tumor angiogenesis. As a key regulator of haemostasis and angiogenesis, it is also involved in the pathology of several diseases, including cardiovascular, inflammatory and neoplastic conditions.

Full Name
coagulation factor III (thromboplastin, tissue factor)
References
  • Morrissey JH. (2004) Tissue factor: a key molecule in hemostatic and nonhemostatic systems. Int J Hematol. 79(2): 103-8.
  • Milsom C, et al. (2008) Tissue factor and cancer. Pathophysiol Haemost Thromb. 36(3-4): 160-76.
  • Kasthuri RS, et al. (2009) Role of tissue factor in cancer. J Clin Oncol. 27(29): 4834-8.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-Tissue Factor Antibody Mouse Monoclonal ELISA(Cap) 80407-MM01
    Anti-Tissue Factor Antibody Rabbit Polyclonal ELISA 80407-T16
    Anti-Tissue Factor Antibody Rabbit Polyclonal ELISA 80407-RP01
    Anti-Tissue Factor Antibody Rabbit Monoclonal WB,ELISA 50413-R034
    Anti-Tissue Factor Antibody Rabbit Polyclonal ELISA 50413-RP01
    Anti-Tissue Factor Antibody Rabbit Monoclonal FCM 50413-R001
    Anti-Tissue Factor Antibody Rabbit Polyclonal ELISA 50413-RP02
    Anti-Tissue Factor Antibody (PE) Rabbit Monoclonal FCM 50413-R001-P
    Anti-Tissue Factor Antibody (PE) Mouse Monoclonal FCM 13133-MM05-P
    Anti-Tissue Factor Antibody Rabbit Monoclonal ELISA 13133-R001
    Anti-Tissue Factor Antibody Mouse Monoclonal ELISA,FCM,ICC/IF,IF 13133-MM05
    Anti-Tissue Factor Antibody (APC) Mouse Monoclonal FCM 13133-MM05-A
    Anti-Tissue Factor Antibody (FITC) Mouse Monoclonal FCM 13133-MM05-F
    Anti-Tissue Factor Antibody Rabbit Polyclonal WB,ELISA,IP 13133-T52
    Anti-Tissue Factor Antibody Rabbit Polyclonal ELISA 13133-RP01
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