Coagulation Factor II Protein (FII, F2 Protein)

Coagulation Factor II Products

Coagulation Factor II Protein, Recombinant

Molecule	Species	Description	Cat. No
Coagulation Factor II	Mouse	Coagulation Factor II/FII/F2 Protein, Recombinant	50344-M08H

Coagulation Factor II cDNA Clone

Molecule	Species	Description	Cat. No
Coagulation Factor II	Human	Homo sapiens Coagulation Factor II/FII/F2 cDNA Clone	HG11505-M
Coagulation Factor II	Mouse	Mus musculus Coagulation Factor II/FII/F2 cDNA Clone	MG50344-M

Coagulation Factor II Related Areas

Enzyme>>Protease & Regulator>>Serine Protease & Regulator>>Coagulation Factor II

Immunology>>Innate Immunity>>Coagulation>>Coagulation Factor II

Cardiovascular>>Coagulation>>Coagulation Factor II

Coagulation Factor II Alternative Names

Coagulation Factor II, FII, F2, PT, prothrombin [Homo sapiens]

Coagulation Factor II, FII, F2, RP23-176N9.4, Cf-2, Cf2, prothrombin, thrombin [Mus musculus]

Coagulation Factor II Background

Coagulation Factor II Protein (FII, F2 Protein or Prothrombin) is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. Coagulation Factor II Protein (FII, F2 Protein) also plays a role in maintaining vascular integrity during development and postnatal life. Prothrombin / Coagulation Factor II is activated on the surface of a phospholipid membrane that binds the amino end of prothrombin / Coagulation Factor II and factor Va and Xa in Ca-dependent interactions; factor Xa removes the activation peptide and cleaves the remaining part into light and heavy chains. The activation process starts slowly because factor V itself has to be activated by the initial, small amounts of thrombin. Prothrombin / Coagulation Factor II is expressed by the liver and secreted in plasma. Defects in prothrombin / Coagulation Factor II are the cause of factor II deficiency (FA2D). It is very rare blood coagulation disorder characterized by mucocutaneous bleeding symptoms. The severity of the bleeding manifestations correlates with blood factor II levels. Defects in Coagulation Factor II are also a cause of susceptibility to thrombosis. It is a multifactorial disorder of hemostasis characterized by abnormal platelet aggregation in response to various agents and recurrent thrombi formation.

Coagulation Factor II Related Studies

1. Danneberg J, et al. (1998) Reliable genotyping of the G-20210-A mutation of Coagulation Factor II (prothrombin). Clin Chem. 44(2): 349-51.
2. Redondo M, et al. (1999) Coagulation Factor s II, V, VII, and X, prothrombin gene 20210G-->A transition, and factor V Leiden in coronary artery disease: high factor V clotting activity is an independent risk factor for myocardial infarction. Arterioscler Thromb Vasc Biol. 19(4): 1020-5.
3. Miletich JP, et al. (1980) The synthesis of sulfated dextran beads for isolation of human plasma Coagulation Factor s II, IX, and X. Anal Biochem. 105(2): 304-10.