Anti-Clusterin Antibody

Cat: 11297-RP01
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Anti-Clusterin Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-Clusterin Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human Clusterin
Immunogen
Recombinant Human Clusterin / Apolipoprotein J / Apo-J protein (Catalog#11297-H08H)
Preparation
Produced in rabbits immunized with purified, recombinant Human Clusterin / Apolipoprotein J / Apo-J (rh Clusterin; Catalog#11297-H08H; NP_001822.2; Met 1-Glu 501). Total IgG was purified by Protein A affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-Clusterin Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-Clusterin Antibody Alternative Names
Anti-AAG4 Antibody;Anti-APO-J Antibody;Anti-APOJ Antibody;Anti-CLI Antibody;Anti-CLU1 Antibody;Anti-CLU2 Antibody;Anti-KUB1 Antibody;Anti-NA1/NA2 Antibody;Anti-SGP-2 Antibody;Anti-SGP2 Antibody;Anti-SP-40 Antibody;Anti-TRPM-2 Antibody;Anti-TRPM2 Antibody
Clusterin Background Information

Clusterin, also known as complement-associated protein SP-40, Complement cytolysis inhibitor, Apolipoprotein J, Testosterone-repressed prostate message 2, Aging-associated gene 4 protein, CLU and APOJ, is a secreted protein which belongs to the clusterin family. Clusterin/Apolipoprotein J/Apo-J is an enigmatic glycoprotein with a nearly ubiquitous tissue distribution and an apparent involvement in biological processes ranging from mammary gland involution to neurodegeneration in Alzheimer's disease. Its major form, a heterodimer, is secreted and present in physiological fluids, but truncated forms targeted to the nucleus have also been identified. Clusterin/Apolipoprotein J/Apo-J is a widely distributed glycoprotein with a wide range of biologic properties. A prominent and defining feature of clusterin is its marked induction in such disease states as glomerulonephritis, cystic renal disease, renal tubular injury, neurodegenerative conditions, atherosclerosis, and myocardial infarction. Upregulation of clusterin mRNA and protein levels detected in diverse disease states and in in vitro systems have led to suggestions that it functions in membrane lipid recycling, in apoptotic cell death, and as a stress-induced secreted chaperone protein, amongst others.

Full Name
clusterin
References
  • Silkensen JR, et al. (1994) The role of clusterin in tissue injury. Biochem Cell Biol. 72(11-12): 483-8.
  • Naik RR, et al. (2002) Biomimetic synthesis and patterning of silver nanoparticles. Nat Mater. 1(3): 169-72.
  • Djeu JY, et al. (2009) Clusterin and chemoresistance. Adv Cancer Res. 105: 77-92.
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