Chymotrypsin C (CTRC)

Chymotrypsin C (abbreviated for CTRC), also known as caldecrin or elastase4, is a digestive enzyme of the peptidase S1 family. This enzyme is synthesized as an inactivate chymotrypsinogen. On cleavage by trypsin into two parts that activate each other by removing two small peptides in a trans-proteolysis, chymotrypsin C produced. N-linked glycosylation of human CTRC is required for efficient folding and secretion, however, the N-linked glycan is unimportant for enzyme activity or inhibitor binding. It has been proposed that CTRC is a key regulator of digestive zymogen activation and a physiological co-activator of digestive carboxypeptidases proCPA1 and proCPA2. Mutations that abolish activity or secretion of CTRC increase the risk for chronic pancreatitis. It's speculated that CTRC might regulate pancreatic cancer cell migration in relation to cytokeratin 18 expression. The pancreatic cancer cell migration ability was downregulated in pancreatic cancer Aspc-1 cells that overexpressed CTRC, whereas the cell migration ability was upregulated in Aspc-1 cells in which CTRC was suppressed.

Chymotrypsin C (CTRC) Related Areas

 

Chymotrypsin C (CTRC) Alternative Names

CLCR, ELA4 [Homo sapiens]

1810044E12Rik, MGC107504 [Mus musculus]

Summaries for Chymotrypsin C (CTRC)

Entrez Gene summary for CTRC:

This CTRC gene encodes a member of the peptidase S1 family. Chymotrypsin C is a serum calcium-decreasing factor that has chymotrypsin-like protease activity. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]

Wikipedia summary for Chymotrypsin C:

Chymotrypsin C, also known as caldecrin or elastase 4 is an enzyme that in humans is encoded by the CTRC gene.

Human Chymotrypsin C (CTRC) Protein General Information

 

• Protein names: Chymotrypsin-C
• Sequence length: 268 AA.
• Catalytic activity: Preferential cleavage: Leu-|-Xaa, Tyr-|-Xaa, Phe-|-Xaa, Met-|-Xaa, Trp-|-Xaa, Gln-|-Xaa, Asn-|-Xaa.
• Sequence similarities: Chymotrypsin C belongs to the peptidase S1 family. Elastase subfamily. Chymotrypsin C contains 1 peptidase S1 domain.
• Tissue specificity: Pancreas.
• Involvement in disease: Note=Genetic variations in CTRC can predispose to chronic pancreatitis by diminishing its protective trypsin-degrading activity.

General information above from UniProt

Function for Chymotrypsin C (CTRC) Protein

UniProtKB:

Chymotrypsin C has chymotrypsin-type protease activity and hypocalcemic activity.

Genatlas:

• Chymotrypsin C is serum calcium decreasing factor
• Chymotrypsin C degrades all trypsin and trypsinogen isoforms with high specificity
• Chymotrypsin C is key regulator of activation and degradation of cationic trypsin (in the high Ca(2+) environment of the duodenum, facilitates trypsinogen activation, whereas in the lower intestines, promotes trypsin degradation as a function of decreasing luminal Ca(2+) concentrations)

Phenotype Information for Chymotrypsin C (CTRC)

• Gene/Locus: CTRC, CLCR
• Phenotype: {Pancreatitis, chronic, susceptibility to}

Phenotype Information for Chymotrypsin C from OMIM (Online Mendelian Inheritance in Man)