0 products, total $0.+86-400-890-9989      Login |  Register 中文한국어

Browse By Molecule:

Your Position: Home > Chromatin Remodeling

Chromatin Remodeling

Chromatin remodeling involves the effective shifting of nucleosome cores, which are composed of histone octamers, that consist of a H3(2):H4(2) tetramer and two dimers of H2A and H2B, along the length of the DNA molecule, a process known as "nucleosome sliding". Recent studies suggest that this shift may involve the actual disassembly and reassembly of the nucleosome core.

Sino Biological offers a comprehensive set of tools for Chromatin Remodeling related studies, including recombinant proteins, antibodies (rabbit mAbs, mouse mAbs, rabbit pAbs), ELISA kits, and ORF cDNA clones.

Chromatin Remodeling Related Products

  Please click the molecular formulas to find products that you are interested.

   * Being developed. Tell us your requirement so that the products of interest be placed on the priority list.

Histone Acetylation

  • KAT8*

Histone Deacetylation (HDAC)

  • HDAC1
  • HDAC10
  • SIRT4*
  • HDAC2
  • HDAC11
  • SIRT5*
  • SIRT6*
  • SIRT2*
  • SIRT7*
  • SIRT3*
 

Histone Methylation

  • SUV39H2*
  • EZH2*
  • SUV420H1*
  • SMYD2*
  • SUV39H1*
 

Histone Demethylation

   

ISWI

 

Chromatin Remodeling Background

Chromatin remodeling involves the effective shifting of nucleosome cores, which are composed of histone octamers, that consist of a H3(2):H4(2) tetramer and two dimers of H2A and H2B, along the length of the DNA molecule, a process known as "nucleosome sliding". Recent studies suggest that this shift may involve the actual disassembly and reassembly of the nucleosome core.

Chromatin remodeling is accomplished, at least in part, by ATPase containing complexes, referred to as the SWI / SNF family. Chromatin remodeling complexes are classed into four subfamilies based upon their associated ATPase. The four ATPases associated with chromatin remodeling complexes are SWI / SNF and Brg1; imitation switch (ISWI); Mi-2 (CHD1) and INO80.

The SWI / SNF complex is a 2 MDa multi-subunit DNA-dependent ATPase that contributes to the regulation of gene transcription by altering chromatin structure. Recent studies have revealed that the SWI / SNF complex is targeted to promoters via direct interactions with transcription activators and have provided insights into mechansims by which the complex alters nucleosome structure and contributes to the remodeling of chromatin.The ISWI complexes are divided into the nucleosome remodeling factor (NURF), chromatin accessibility complex (CHRAC), and ATP-dependent chromatin and remodeling factor (ACF) complexes. NURF is composed of ISWI and three additional subunits, NURF301, NURF55 and NURF38. The SWI/SNF family members differentiate at the level of DNA sequence and gene structure.

Chromatin Remodeling Related Studies

    1. Wilson CJ, et al. (1996) RNA polymerase II holoenzyme contains SWI / SNF regulators involved in chromatin remodeling. Cell. 84(2): 235-44.
    2. Peterson CL, et al. (2000) Promoter targeting and chromatin remodeling by the SWI / SNF complex. Curr Opin Genet Dev. 10(2): 187-92.
    3. Xue Y, et al. (1998) NURD, a novel complex with both ATP-dependent chromatin-remodeling and histone deacetylase activities. Mol Cell. 2(6): 851-61.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
_×