Cathepsin V (Cathepsin L2, Preproprotein)

Cathepsin V (CTSV), also known as Cathepsin L2, CTSL2, and CATL2, is a member of the peptidase C1 family. It is predominantly expressed in the thymus and testis. Cathepsin V is also expressed in corneal epithelium, and to a lesser extent in conjuctival epithelium and skin. It is a lysosomal cysteine proteinase that may play an important role in corneal physiology. It has about 75% protein sequence identity to murine cathepsin L. The fold of this enzyme is similar to the fold adopted by other members of the papain superfamily of cysteine proteases. Cathepsin V has been recently described as highly homologous to Cathepsin L and exclusively expressed in human thymus and testis. Cathepsin V is the dominant cysteine protease in cortical human thymic epithelial cells, while Cathepsin L and Cathepsin S seem to be restricted to dendritic and macrophage-like cells. Active Cathepsin V in thymic lysosomal preparations was demonstrated by active-site labeling. Recombinant Cathepsin V was capable of converting Ii into CLIP efficiently, suggesting that it is the protease that controls the generation of alphabeta-CLIP complexes in the human thymus. Cathepsin V is the third elastolytic cysteine protease which exhibits the most potent elastase activity yet described among human proteases and that it is present in atherosclerotic plaque specimens. Cathepsin L2 may play a specialized role in the thymus and testis. Expression analysis of cathepsin L2 in human tumors revealed a widespread expression in colorectal and breast carcinomas but not in normal colon or mammary gland or in peritumoral tissues. Cathepsin L2 was also expressed by colorectal and breast cancer cell lines as well as by some tumors of diverse origin, including ovarian and renal carcinomas.

Cathepsin V (Cathepsin L2, Preproprotein) Related Areas

Enzyme>>Protease & Regulator>>Cysteine Protease & Regulator>>Cathepsin Family>>Cathepsin V/Cathepsin L2

Cancer>>Angiogenesis>>Cathepsin Family>>Cathepsin V/Cathepsin L2

Immunology>>Innate Immunity>>Lysosomal Enzyme>>Cathepsin Family>>Cathepsin V/Cathepsin L2

Cathepsin V (Cathepsin L2, Preproprotein) Alternative Names

Cathepsin V, Cathepsin L2, preproprotein, CTSV, CATL2, CTSU, Cathepsin U, MGC125957

Summaries for Cathepsin V (Cathepsin L2, Preproprotein)

Entrez Gene summary for Cathepsin V (Cathepsin L2, Preproprotein):

The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may play an important role in corneal physiology. This gene is expressed in colorectal and breast carcinomas but not in normal colon, mammary gland, or peritumoral tissues, suggesting a possible role for this gene in tumor processes. Alternatively spliced variants, encoding the same protein, have been identified.

OMIM - description for Cathepsin V (Cathepsin L2, Preproprotein):

Cathepsins are members of the papain family of cysteine proteinases and are involved in many normal cellular processes and a number of pathologic conditions. Cysteine proteinases are synthesized as preproenzymes, which are processed to the corresponding proenzymes. The proenzymes are either targeted to the lysosome or continue along the cellular secretory route.

Wikipedia summary for Cathepsin V (Cathepsin L2, Preproprotein):

Cathepsin L2, also known as cathepsin V and encoded by the CTSL2 gene, is a human gene. The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may play an important role in corneal physiology. This gene is expressed in colorectal and breast carcinomas but not in normal colon, mammary gland, or peritumoral tissues, suggesting a possible role for this gene in tumor processes.

Human Cathepsin V (Cathepsin L2, Preproprotein) Protein General Information

 

• Protein names: Recommended name: Cathepsin L2
• Sequence length: 334 AA.
• Domain: Signal
• Sequence similarities: Belongs to the peptidase C1 family.
• Catalytic activity: The recombinant enzyme hydrolyzes proteins (serum albumin, collagen) and synthetic substrates (Z-Phe-Arg-NHMec > Z-Leu-Arg-NHMec > Z-Val-Arg-NHMec).
• Subcellular location: Lysosome
• Tissue specificity: Predominantly expressed in the thymus and testis. Also expressed in corneal epithelium, and to a lesser extent in conjunctival epithelium and skin.

General information above from UniProt

Function for Cathepsin V (Cathepsin L2, Preproprotein) Protein

UniProtKB:

Cysteine protease. May have an important role in corneal physiology.

Genatlas:

• cysteine proteinase playing an important role in corneal physiology
• Cathepsin V (Cathepsin L2, Preproprotein) is involved in tumor processes perhaps
• Cathepsin V (Cathepsin L2, Preproprotein) has multiple cell type-specific functions in the heart
• Cathepsin V (Cathepsin L2, Preproprotein) maybe involved in complex integrity

Homology for human Cathepsin V (Cathepsin L2, Preproprotein)

• homolog to murine Ctsl,Ctsm,Cts8
• homolog to Drosophila Cp1
• homolog to C.elegans to3e6.7/cpl-1
• homolog to rattus Ctsl,Rn.10029,Ctsj