Cathepsin E (CTSE)

Cathepsin E Protein (CTSE Protein) is a member of the peptidase C1 family that is a gastric aspartic protease that functions as a disulfide-linked homodimer. Cathepsin E Protein (CTSE Protein) is predominantly present in the cells of immune system and is frequently implicated in antigen processing via the MHC classⅡ pathway which however does not appear to be involved in the digestion of dietary protein. The protein has a specificity similar to that of pepsin and pepsin. Cathepsin E Protein (CTSE Protein) is found in highest concentration in the surface of epithelial mucus-producing cells of the stomach and also been found in more than half of the gastric cancers. It appears, therefore, to be an oncofetal antigen.

Cathepsin E (CTSE) Related Areas

Enzyme>>Protease & Regulator>>Aspartate Protease & Regulator>>Cathepsin E/CTSE

Cancer>>Angiogenesis>>Cathepsin Family>>Cathepsin E/CTSE

Immunology>>Innate Immunity>>Lysosomal Enzyme>>Cathepsin Family>>Cathepsin E/CTSE

Cathepsin E (CTSE) Alternative Names

Cathepsin E, CTSE, CATE [Homo sapiens]

Cathepsin E, Ctse, A430072O03Rik, C920004C08Rik, CE, CatE [Mus musculus]

Summaries for Cathepsin E (CTSE)

Entrez Gene summary for Cathepsin E (CTSE) :

The protein encoded by this gene is a gastric aspartyl protease that functions as a disulfide-linked homodimer. This protease, which is a member of the peptidase C1 family, has a specificity similar to that of pepsin A and cathepsin D. It is an intracellular proteinase that does not appear to be involved in the digestion of dietary protein and is found in highest concentration in the surface of epithelial mucus-producing cells of the stomach. It is the first aspartic proteinase expressed in the fetal stomach and is found in more than half of gastric cancers. It appears, therefore, to be an oncofetal antigen. Transcript variants utilizing alternative polyadenylation signals and two transcript variants encoding different isoforms exist for this gene. [

OMIM - description for Cathepsin E (CTSE) :

Cathepsin C, or dipeptidyl aminopeptidase I (EC 3.4.14.1), is a lysosomal protease capable of removing dipeptides from the amino terminus of protein substrates. Unlike cathepsins B (116810), H(116820), L (116880), and S (116845), which are small monomeric enzymes, cathepsin C is a large (200 kD) oligomeric protein (Paris et al. (1995)).

Wikipedia summary for Cathepsin E (CTSE) :

Cathepsin E is a protein that in humans is encoded by the CTSE gene. The protein encoded by this gene is a gastric aspartyl protease that functions as a disulfide-linked homodimer. This protease, which is a member of the peptidase A1 family, has a specificity similar to that of pepsin A and cathepsin D. It is an intracellular proteinase that does not appear to be involved in the digestion of dietary protein and is found in highest concentration in the surface of epithelial mucus-producing cells of the stomach. It is the first aspartic proteinase expressed in the fetal stomach and is found in more than half of gastric cancers. It appears, therefore, to be an oncofetal antigen. Transcript variants utilizing alternative polyadenylation signals and two transcript variants encoding different isoforms exist for this gene

Human Cathepsin E (CTSE) Protein General Information

 

• Protein names: Recommended name: Cathepsin E
• Sequence length: 401 AA.
• Domain: Signal
• Sequence similarities: Belongs to the peptidase A1 family.
• Post-translational modification: Glycosylated. The nature of the carbohydrate chain varies between cell types. In fibroblasts, the proenzyme contains a high mannose-type oligosaccharide, while the mature enzyme contains a complex-type oligosaccharide. In erythrocyte membranes, both the proenzyme and mature enzyme contain a complex-type oligosaccharide
• Subunit structure: Homodimer; disulfide-linked.
• Subcellular location: Endosome. Note: The proenzyme is localized to the endoplasmic reticulum and Golgi apparatus, while the mature enzyme is localized to the endosome.
• Tissue specificity: Expressed abundantly in the stomach, the Clara cells of the lung and activated B-lymphocytes, and at lower levels in lymph nodes, skin and spleen. Not expressed in resting B-lymphocytes.

General information above from UniProt

Function for Cathepsin E (CTSE) Protein

UniProtKB:

May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain.

Genatlas:

• endolysosomal aspartic proteinase predominantly expressed in cells of the immune system, having an important role in immune responses
• major intracellular aspartic protease which is predominantly present in the cells of immune system and is frequently implicated in antigen processing via the MHC class II pathway
• Cathepsin E (CTSE) may play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain
• Cathepsin E (CTSE) plays an important role for preventing the accumulation of the lysosomal membrane sialoglycoproteins
• Cathepsin E (CTSE) plays an important role for exogenous antigen processing via the major histocompatibility complex class II presenting system
• Cathepsin E (CTSE) specifically induces tumor growth arrest and apoptosis in prostate carcinoma cell lines without affecting normal cells (Zaidi 2008)
• Cathepsin E (CTSE) is important in the processing of tetanus toxin C-fragment in primary B cells

Homology for human Cathepsin E (CTSE)

• paralog to cathepsins
• homolog to highly homologous to the lysosomal aspartic protease cathepsin D

Phenotype Information for Cathepsin E (CTSE)

• Gene/Locus: CTSC, CPPI, PALS, PLS, HMS, JPD
• Phenotype: Haim-Munk syndrome Papillon-Lefevre syndrome

Phenotype Information for Cathepsin E (CTSE) from OMIM (Online Mendelian Inheritance in Man)