Cathepsin Z / Cathepsin X Protein & Antibody (CTSZ, CTSX)

Cathepsin Z / Cathepsin X Products

Cathepsin Z / Cathepsin X Protein, Recombinant

Molecule	Species	Description	Cat. No
Cathepsin Z/Cathepsin X	Human	CTSZ Protein, Recombinant	10159-H08H
Cathepsin Z/Cathepsin X	Mouse	Cathepsin Z/Cathepsin X  Protein, Recombinant	50089-M08H

  50089-M08H:  activity > 1,100 pmoles / min / μg Cathepsin Z Protein (50089-M08H) Activity: Measured by its ability to cleave the fluorogenic peptide substrate, Mca-RPPGFSAFK(Dnp)-OH ( R&D Systems, Catalog # ES005 )

Cathepsin Z / Cathepsin X Antibody

Molecule	Application	Description	Cat. No
Mouse Cathepsin Z/Cathepsin X	WB, ELISA	Rabbit Polyclonal Antibody	50089-RP01
Mouse Cathepsin Z/Cathepsin X	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	50089-RP02

Cathepsin Z / Cathepsin X cDNA Clone

Molecule	Species	Description	Cat. No
Cathepsin Z/Cathepsin X	Human	Homo sapiens Cathepsin Z/Cathepsin X cDNA Clone(NM_001336.2)	HG10159-M
Cathepsin Z/Cathepsin X	Mouse	Mus musculus Cathepsin Z/Cathepsin X cDNA Clone	MG50089-M

Cathepsin Z / Cathepsin X Related Areas

Enzyme>>Protease & Regulator>>Cysteine Protease & Regulator>>Cathepsin Family>>Cathepsin Z/Cathepsin X

Cancer>>Angiogenesis>>Cathepsin Family>>Cathepsin Z/Cathepsin X

Immunology>>Innate Immunity>>Lysosomal Enzyme>>Cathepsin Family>>Cathepsin Z/Cathepsin X

Cathepsin Z / Cathepsin X Alternative Names

Cathepsin Z, Cathepsin X, CTSZ, CTSX, FLJ17088 [Homo sapiens]

Cathepsin Z, Cathepsin X, Ctsz, CTSX, RP23-59M10.3, AI787083, AU019819, D2Wsu143e [Mus musculus]

Cathepsin Z / Cathepsin X Related Products

Protein Products

Molecule	Species	Description
Cathepsin A/CTSA	Human	Cathepsin A/CTSA Protein, Recombinant
Cathepsin A/CTSA	Mouse	Cathepsin A/CTSA Protein, Recombinant
Cathepsin B/CTSB	Human	Cathepsin B/CTSB Protein, Recombinant
Cathepsin B/CTSB	Mouse	Cathepsin B/CTSB Protein, Recombinant
Cathepsin C/DPP1/CTSC	Mouse	Cathepsin C/DPP1/CTSC Protein, Recombinant
Cathepsin D/CTSD	Mouse	Cathepsin D/CTSD Protein, Recombinant
Cathepsin E/CTSE	Mouse	Cathepsin E/CTSE Protein, Recombinant
Cathepsin L/CTSL/CTSL1	Human	Cathepsin L/CTSL Protein, Recombinant
Cathepsin L/CTSL/CTSL1	Mouse	Cathepsin L/CTSL Protein, Recombinant
Cathepsin S/CTSS	Human	Cathepsin S/CTSS Protein, Recombinant
Cathepsin V/Cathepsin L2	Human	Cathepsin V/Cathepsin L2 Protein, Recombinant

Antibody Products

Molecule	Application	Description
Human Cathepsin A/CTSA	WB	Cathepsin A/CTSA Antibody, Mouse MAb
Human Cathepsin A/CTSA	ELISA	Cathepsin A/CTSA Antibody, Mouse MAb
Human Cathepsin A/CTSA	WB, ELISA	Rabbit Polyclonal Antibody
Human Cathepsin A/CTSA	WB, ELISA	Cathepsin A/CTSA Antibody, Rabbit PAb (Antigen Affinity Purified)
Mouse Cathepsin A/CTSA	WB, ELISA	Cathepsin A/CTSA Antibody, Rabbit PAb
Mouse Cathepsin A/CTSA	WB, ELISA	Cathepsin A/CTSA Antibody, Rabbit PAb (Antigen Affinity Purified)
Mouse Cathepsin D/CTSD	WB, ELISA	Rabbit Polyclonal Antibody
Mouse Cathepsin D/CTSD	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)
Human Cathepsin L/CTSL/CTSL1	WB, ELISA	Cathepsin L/CTSL Antibody, Rabbit PAb
Human Cathepsin L/CTSL/CTSL1	WB, ELISA	Cathepsin L/CTSL Antibody, Rabbit PAb (Antigen Affinity Purified)

cDNA Clone Products

Molecule	Species	Description
Cathepsin A/CTSA	Human	Homo sapiens Cathepsin A/CTSA cDNA Clone(NM_001127695.1)
Cathepsin A/CTSA	Mouse	Mus musculus Cathepsin A/CTSA cDNA Clone
Cathepsin B/CTSB	Human	Homo sapiens Cathepsin B/CTSB cDNA Clone(NM_001908.3)
Cathepsin B/CTSB	Mouse	Mus musculus Cathepsin B/CTSB cDNA Clone
Cathepsin C/DPP1/CTSC	Human	Homo sapiens Cathepsin C/DPP1/CTSC cDNA Clone(NM_001814.4)
Cathepsin C/DPP1/CTSC	Mouse	Mus musculus Cathepsin C/DPP1/CTSC cDNA Clone
Cathepsin D/CTSD	Mouse	Mus musculus Cathepsin D/CTSD cDNA Clone
Cathepsin E/CTSE	Human	Homo sapiens Cathepsin E/CTSE cDNA Clone(NM_001910.2)
Cathepsin E/CTSE	Mouse	Mus musculus Cathepsin E/CTSE cDNA Clone
Cathepsin H/CTSH	Mouse	Mus musculus Cathepsin H/CTSH cDNA Clone
Cathepsin K/CTSK	Human	Homo sapiens Cathepsin K/CTSK cDNA Clone(NM_000396.2)
Cathepsin K/CTSK	Mouse	Mus musculus Cathepsin K/CTSK cDNA Clone
Cathepsin L/CTSL/CTSL1	Human	Homo sapiens Cathepsin L/CTSL cDNA Clone(NM_001912.4)
Cathepsin L/CTSL/CTSL1	Mouse	Mus musculus Cathepsin L/CTSL cDNA Clone
Cathepsin O/CTSO	Human	Homo sapiens Cathepsin O/CTSO cDNA Clone
Cathepsin V/Cathepsin L2	Human	Homo sapiens Cathepsin V/Cathepsin L2 cDNA Clone(NM_001333.2)
Cathepsin S/CTSS	Human	Homo sapiens Cathepsin S/CTSS cDNA Clone(NM_004079.3)

Cathepsin Z / Cathepsin X Background

Cathepsin Z (CTSZ), also known as Cathepsin X or CATX, belongs to the C1 family of lysosomal cysteine proteases. Its gene structure and activity properties show several unique features that distinguish it clearly from other human cysteine proteases. It has a very short pro-region that shows no similarity to those of other cathepsins and a three-residue insertion motif that forms a characteristic ‘mini loop’. Cathepsin Z exhibits mono- and di-peptidase activity at its C-terminus, and in contrast to cathepsin B, it does not act as an endopeptidase. It is restricted to the cells of theimmune system, predominantly monocytes, macrophages and dendritic cells. Cathepsin Z is widely expressed in human tissues, suggesting that this enzyme could be involved in the normal intracellular protein degradation taking place in all cell types. It is capable to cleave regulatory motifs at C-terminus affecting the function of targeted molecules. Cathepsin X may regulate also the maturation of dendritic cells, a process, which is crucial in the initiation of adaptive immunity. Furthermore, higher levels of Cathepsin Z are also found in tumour and immune cells of prostate and gastric carcinomas and inmacrophages of gastric mucosa, especially after infection by Helicobacter pylori. Cathepsin Z is also ubiquitously distributed in cancer cell lines and in primary tumors from different sources, suggesting that this enzyme may participate in tumor progression.

Cathepsin Z / Cathepsin X Related Studies

1. Santamaría I, et al. (1998) Cathepsin Z, a novel human cysteine proteinase with a short propeptide domain and a unique chromosomal location. J Biol Chem. 273(27): 16816-23.
2. Kos J, et al. (2009) The role of cathepsin X in cell signaling. Cell Adh Migr. 3(2): 164-6.
3. Sevenich L, et al. (2010) Synergistic antitumor effects of combined cathepsin B and cathepsin Z deficiencies on breast cancer progression and metastasis in mice. Proc Natl Acad Sci U S A. 107(6): 2497-502.