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> Cathepsin V / Cathepsin L2 Protein (Preproprotein) Cathepsin V / Cathepsin L2 Protein (Preproprotein)
Cathepsin V / Cathepsin L2 Products
Cathepsin V / Cathepsin L2 Protein, Recombinant
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| Cathepsin V/Cathepsin L2 | Human | Cathepsin V/Cathepsin L2 Protein, Recombinant |
10093-H08H |
Cathepsin V / Cathepsin L2 cDNA Clone
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| Cathepsin V/Cathepsin L2 | Human | Homo sapiens Cathepsin V/Cathepsin L2 cDNA Clone(NM_001333.2) | HG10093-M |
Cathepsin V / Cathepsin L2 Related Areas
Enzyme>>Protease & Regulator>>Cysteine Protease & Regulator>>Cathepsin Family>>Cathepsin V/Cathepsin L2
Cancer>>Angiogenesis>>Cathepsin Family>>Cathepsin V/Cathepsin L2
Immunology>>Innate Immunity>>Lysosomal Enzyme>>Cathepsin Family>>Cathepsin V/Cathepsin L2
Cathepsin V / Cathepsin L2 Alternative Names
Cathepsin V, Cathepsin L2, preproprotein, CTSV, CATL2, CTSU, Cathepsin U, MGC125957
Cathepsin V / Cathepsin L2 Related Products
Protein Products
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! |
| Cathepsin A/CTSA | Human | Cathepsin A/CTSA Protein, Recombinant |
| Cathepsin A/CTSA | Mouse | Cathepsin A/CTSA Protein, Recombinant |
| Cathepsin B/CTSB | Human | Cathepsin B/CTSB Protein, Recombinant |
| Cathepsin B/CTSB | Mouse | Cathepsin B/CTSB Protein, Recombinant |
| Cathepsin C/DPP1/CTSC | Mouse | Cathepsin C/DPP1/CTSC Protein, Recombinant |
| Cathepsin D/CTSD | Mouse | Cathepsin D/CTSD Protein, Recombinant |
| Cathepsin E/CTSE | Mouse | Cathepsin E/CTSE Protein, Recombinant |
| Cathepsin L/CTSL/CTSL1 | Human | Cathepsin L/CTSL Protein, Recombinant |
| Cathepsin L/CTSL/CTSL1 | Mouse | Cathepsin L/CTSL Protein, Recombinant |
| Cathepsin S/CTSS | Human | Cathepsin S/CTSS Protein, Recombinant |
| Cathepsin Z/Cathepsin X | Mouse | Cathepsin Z/Cathepsin X Protein, Recombinant |
Antibody Products
cDNA Clone Products
Cathepsin V / Cathepsin L2 Background
Cathepsin V (CTSV), also known as Cathepsin L2, CTSL2, and CATL2, is a member of the peptidase C1 family. It is predominantly expressed in the thymus and testis. Cathepsin V is also expressed in corneal epithelium, and to a lesser extent in conjuctival epithelium and skin. It is a lysosomal cysteine proteinase that may play an important role in corneal physiology. It has about 75% protein sequence identity to murine cathepsin L. The fold of this enzyme is similar to the fold adopted by other members of the papain superfamily of cysteine proteases. Cathepsin V has been recently described as highly homologous to Cathepsin L and exclusively expressed in human thymus and testis. Cathepsin V is the dominant cysteine protease in cortical human thymic epithelial cells, while Cathepsin L and Cathepsin S seem to be restricted to dendritic and macrophage-like cells. Active Cathepsin V in thymic lysosomal preparations was demonstrated by active-site labeling. Recombinant Cathepsin V was capable of converting Ii into CLIP efficiently, suggesting that it is the protease that controls the generation of alphabeta-CLIP complexes in the human thymus. Cathepsin V is the third elastolytic cysteine protease which exhibits the most potent elastase activity yet described among human proteases and that it is present in atherosclerotic plaque specimens. Cathepsin L2 may play a specialized role in the thymus and testis. Expression analysis of cathepsin L2 in human tumors revealed a widespread expression in colorectal and breast carcinomas but not in normal colon or mammary gland or in peritumoral tissues. Cathepsin L2 was also expressed by colorectal and breast cancer cell lines as well as by some tumors of diverse origin, including ovarian and renal carcinomas.
Cathepsin V / Cathepsin L2 Related Studies
- Itoh R, et al. (1999) Genomic organization and chromosomal localization of the human cathepsin L2 gene. DNA Res. 6(2): 137-40.
- Tolosa E, et al. (2003) Cathepsin V is involved in the degradation of invariant chain in human thymus and is overexpressed in myasthenia gravis. J Clin Invest. 112(4): 517-26.
- Yasuda Y, et al. (2004) Cathepsin V, a novel and potent elastolytic activity expressed in activated macrophages. J Biol Chem. 279(35): 36761-70.
- Puzer L, et al. (2008) Cathepsin V, but not cathepsins L, B and K, may release angiostatin-like fragments from plasminogen. Biol Chem. 389(2): 195-200.
