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> Cathepsin L Protein & Antibody (CTSL/CTSL1) Cathepsin L Protein & Antibody (CTSL/CTSL1)
Cathepsin L Products
Cathepsin L Protein, Recombinant
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| Cathepsin L/CTSL/CTSL1 | Human | Cathepsin L/CTSL Protein, Recombinant |
10486-H08H |
| Cathepsin L/CTSL/CTSL1 | Mouse | Cathepsin L/CTSL Protein, Recombinant | 50015-M08H |
Cathepsin L Antibody
| Molecule | Application | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| Human Cathepsin L/CTSL/CTSL1 |
WB, ELISA | Cathepsin L/CTSL Antibody, Rabbit PAb | 10486-RP01 |
| Human Cathepsin L/CTSL/CTSL1 |
WB, ELISA | Cathepsin L/CTSL Antibody, Rabbit PAb (Antigen Affinity Purified) | 10486-RP02 |
| Mouse Cathepsin L/CTSL/CTSL1 |
WB, ELISA | Cathepsin L / CTSL Antibody (Antigen Affinity Purified) | 50015-RP02 |
Cathepsin L cDNA Clone
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| Cathepsin L/CTSL/CTSL1 | Human | Homo sapiens Cathepsin L/CTSL cDNA Clone(NM_001912.4) | HG10486-M |
| Cathepsin L/CTSL/CTSL1 | Mouse | Mus musculus Cathepsin L/CTSL cDNA Clone | MG50015-M |
Cathepsin L Related Areas
Enzyme>>Protease & Regulator>>Cysteine Protease & Regulator>>Cathepsin Family>>Cathepsin L/CTSL/CTSL1
Cancer>>Angiogenesis>>Cathepsin Family>>Cathepsin L/CTSL/CTSL1
Immunology>>Innate Immunity>>Lysosomal Enzyme>>Cathepsin Family>>Cathepsin L/CTSL/CTSL1
Cathepsin L Alternative Names
Cathepsin L, Cathepsin L1, CTSL, CTSL1, CATL, FLJ31037, MEP [Homo sapiens]
Cathepsin L, Cathepsin L1, Ctsl, Ctsl1, 1190035F06Rik, MEP, fs, nkt [Mus musculus]
Cathepsin L Related Products
Protein Products
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! |
| Cathepsin A/CTSA | Human | Cathepsin A/CTSA Protein, Recombinant |
| Cathepsin A/CTSA | Mouse | Cathepsin A/CTSA Protein, Recombinant |
| Cathepsin B/CTSB | Human | Cathepsin B/CTSB Protein, Recombinant |
| Cathepsin B/CTSB | Mouse | Cathepsin B/CTSB Protein, Recombinant |
| Cathepsin C/DPP1/CTSC | Mouse | Cathepsin C/DPP1/CTSC Protein, Recombinant |
| Cathepsin D/CTSD | Mouse | Cathepsin D/CTSD Protein, Recombinant |
| Cathepsin E/CTSE | Mouse | Cathepsin E/CTSE Protein, Recombinant |
| Cathepsin S/CTSS | Human | Cathepsin S/CTSS Protein, Recombinant |
| Cathepsin V/Cathepsin L2 | Human | Cathepsin V/Cathepsin L2 Protein, Recombinant |
| Cathepsin Z/Cathepsin X | Mouse | Cathepsin Z/Cathepsin X Protein, Recombinant |
Antibody Products
| Molecule | Application | Description //For Detailed Info. and Price------CLICK! |
| Human Cathepsin A/CTSA |
WB | Cathepsin A/CTSA Antibody, Mouse MAb |
| Human Cathepsin A/CTSA |
ELISA | Cathepsin A/CTSA Antibody, Mouse MAb |
| Human Cathepsin A/CTSA |
WB, ELISA | Rabbit Polyclonal Antibody |
| Human Cathepsin A/CTSA |
WB, ELISA | Cathepsin A/CTSA Antibody, Rabbit PAb (Antigen Affinity Purified) |
| Mouse Cathepsin A/CTSA |
WB, ELISA | Cathepsin A/CTSA Antibody, Rabbit PAb |
| Mouse Cathepsin A/CTSA |
WB, ELISA | Cathepsin A/CTSA Antibody, Rabbit PAb (Antigen Affinity Purified) |
| Mouse Cathepsin D/CTSD |
WB, ELISA | Rabbit Polyclonal Antibody |
| Mouse Cathepsin D/CTSD |
WB, ELISA | Rabbit Polyclonal Antibody (Antigen Affinity Purified) |
| Mouse Cathepsin Z/Cathepsin X |
WB, ELISA | Rabbit Polyclonal Antibody |
| Mouse Cathepsin Z/Cathepsin X |
WB, ELISA | Rabbit Polyclonal Antibody (Antigen Affinity Purified) |
cDNA Clone Products
Cathepsin L Background
Cathepsin L is a lysosomal cysteine protease that plays a major role in intracellular protein catabolism, and is potent in degrading collagen, laminin, elastin, as well as alpha-1 protease inhibitor and other structural proteins of basement membranes. It is secreted by liver flukes at all stages of their development in the mammalian host, are believed to play important roles in facilitating parasite migration (tissue degradation), feeding and immuno-evasion. Like many proteases, Cathepsin L is synthesized as an inactive preproenzyme, and cleavage of the 96-residue proregion is necessary to generate the fully active 221-residue mature enzyme. Studies have demonstrated that cleavage of the proregion occur autocatalytically under acidic conditions. The enzyme takes part in nutrient acquisition by catabolizing host proteins to absorbable peptides, facilitates the migration of the parasite through the host intestine and liver by cleaving interstitial matrix proteins such as fibronectin, laminin and native collagen and is implicated in the inactivation of host immune defenses by cleaving immunoglobulins. Recently, Cathepsin L has been shown to suppress Th1 immune response in infected laboratory animals making them susceptible to concurrent bacterial infections. Cathepsin L is synthesized in large amounts and secreted by many malignantly transformed cells, and induced by growth factors and tumor promoters. In addition to its role in protein degradation, evidence has accumulated for the participation of Cathepsin L in various physiological and pathological processes, such as tumor invasion and metastasis, bone resorption, spermatogenesis, and arthritis. Accordingly, Cathepsin L may prove useful as a diagnostic or prognostic marker of human tumor malignancy.
Cathepsin L Related Studies
- Mulcahy G, et al. (2001) Cathepsin L proteinases as vaccines against infection with Fasciola hepatica (liver fluke) in ruminants. Res Vet Sci. 70(1): 83-6.
- Dixit AK, et al. (2008) Immunodiagnostic/protective role of cathepsin L cysteine proteinases secreted by Fasciola species. Vet Parasitol. 154(3-4): 177-84.
- Leto G, et al. (2010) Cathepsin L in metastatic bone disease: therapeutic implications. Biol Chem. 391(6): 655-64.
