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Cathepsin L1 / CTSL1 Antibody, Rabbit PAb, Antigen Affinity Purified

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Human CTSL1 Antibody Product Information
Immunogen:Recombinant Human CTSL1 protein (Catalog#10486-H08H)
Clone ID:
Ig Type:Rabbit IgG
Concentration:
Endotoxin:
Formulation:0.2 μm filtered solution in PBS with 5% trehalose
Preparation:Produced in rabbits immunized with purified, recombinant Human Cathepsin-L1 / CTSL1 (rh CTSL1; Catalog#10486-H08H; NP_001903.1; Met 1-Val 333). CTSL1 specific IgG was purified by human CTSL1 affinity chromatography.
Human CTSL1 Antibody WB Application Image
Other CTSL1 Antibody Products
Reactivity: Human  
Application: ELISA  
    10486-MM07-50
    10486-MM07-200
    10486-MM07-100
    50 µg 
    200 µg 
    100 µg 
    Add to Cart
    Reactivity: Human  
    Application: ELISA  
      10486-R002-50
      10486-R002-100
      50 µg 
      100 µg 
      Add to Cart
      Reactivity: Human  
      Application: WB  
      • Slide 1
      10486-R221-50
      10486-R221-100
      50 µg 
      100 µg 
      Add to Cart
      Reactivity: Human  
      Application: ELISA  
        10486-RP01-400
        10486-RP01-200
        10486-RP01-100
        400 µg 
        200 µg 
        100 µg 
        Add to Cart
        Reactivity: Mouse  
        Application: ELISA  WB  IP  
        • Slide 1
        • Slide 1
        50015-RP02-50
        50015-RP02-200
        50015-RP02-100
        50 µg 
        200 µg 
        100 µg 
        Add to Cart
        Reactivity: Mouse  
        Application: ELISA  
          50015-RP01-400
          50015-RP01-200
          50015-RP01-100
          400 µg 
          200 µg 
          100 µg 
          Add to Cart
          Cathepsin L/CTSL1 Background

          Cathepsin L is a lysosomal cysteine protease that plays a major role in intracellular protein catabolism, and is potent in degrading collagen, laminin, elastin, as well as alpha-1 protease inhibitor and other structural proteins of basement membranes. It is secreted by liver flukes at all stages of their development in the mammalian host, are believed to play important roles in facilitating parasite migration (tissue degradation), feeding and immuno-evasion. Like many proteases, Cathepsin L is synthesized as an inactive preproenzyme, and cleavage of the 96-residue proregion is necessary to generate the fully active 221-residue mature enzyme. Studies have demonstrated that cleavage of the proregion occur autocatalytically under acidic conditions. The enzyme takes part in nutrient acquisition by catabolizing host proteins to absorbable peptides, facilitates the migration of the parasite through the host intestine and liver by cleaving interstitial matrix proteins such as fibronectin, laminin and native collagen and is implicated in the inactivation of host immune defenses by cleaving immunoglobulins. Recently, Cathepsin L has been shown to suppress Th1 immune response in infected laboratory animals making them susceptible to concurrent bacterial infections. Cathepsin L is synthesized in large amounts and secreted by many malignantly transformed cells, and induced by growth factors and tumor promoters. In addition to its role in protein degradation, evidence has accumulated for the participation of Cathepsin L in various physiological and pathological processes, such as tumor invasion and metastasis, bone resorption, spermatogenesis, and arthritis. Accordingly, Cathepsin L may prove useful as a diagnostic or prognostic marker of human tumor malignancy.

          Human Cathepsin L/CTSL1 References
        • Mulcahy G, et al. (2001) Cathepsin L proteinases as vaccines against infection with Fasciola hepatica (liver fluke) in ruminants. Res Vet Sci. 70(1): 83-6.
        • Dixit AK, et al. (2008) Immunodiagnostic/protective role of cathepsin L cysteine proteinases secreted by Fasciola species. Vet Parasitol. 154(3-4): 177-84.
        • Leto G, et al. (2010) Cathepsin L in metastatic bone disease: therapeutic implications. Biol Chem. 391(6): 655-64.
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          All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
          Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"