Cathepsin D Protein & Antibody (CTSD)

Cathepsin D Products

Cathepsin D Protein, Recombinant

Molecule	Species	Description	Cat. No
Cathepsin D/CTSD	Mouse	Cathepsin D/CTSD Protein, Recombinant	50127-M08H
Cathepsin D/CTSD	Human	Cathepsin D / CTSD Protein, Recombinant	12517-H08H

Cathepsin D Antibody

Molecule	Application	Description	Cat. No
Mouse Cathepsin D/CTSD	WB, ELISA	Rabbit Polyclonal Antibody	50127-RP01
Mouse Cathepsin D/CTSD	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	50127-RP02
Mouse Cathepsin D/CTSD	WB, ELISA	Cathepsin D Antibody	50127-R102

Cathepsin D cDNA Clone Products

Molecule	Species	Description	Cat. No
Cathepsin D/CTSD	Mouse	Mus musculus Cathepsin D/CTSD cDNA Clone	MG50127-M

Cathepsin D Related Areas

Enzyme>>Protease & Regulator>>Aspartate Protease & Regulator>>Cathepsin D/CTSD

Cancer>>Angiogenesis>>Cathepsin Family>>Cathepsin D/CTSD

Cancer>>Cancer Biomarkers>>Cathepsin Family>>Cathepsin D/CTSD

Immunology>>Innate Immunity>>Lysosomal Enzyme>>Cathepsin Family>>Cathepsin D/CTSD

Cathepsin D Alternative Names

Cathepsin D, CTSD, CLN10, CPSD, MGC2311 [Homo sapiens]

Cathepsin D, Ctsd, CD, CatD [Mus musculus]

Cathepsin D Related Products

Protein Products

Molecule	Species	Description
Cathepsin A/CTSA	Human	Cathepsin A/CTSA Protein, Recombinant
Cathepsin A/CTSA	Mouse	Cathepsin A/CTSA Protein, Recombinant
Cathepsin B/CTSB	Human	Cathepsin B/CTSB Protein, Recombinant
Cathepsin B/CTSB	Mouse	Cathepsin B/CTSB Protein, Recombinant
Cathepsin C/DPP1/CTSC	Mouse	Cathepsin C/DPP1/CTSC Protein, Recombinant
Cathepsin E/CTSE	Mouse	Cathepsin E/CTSE Protein, Recombinant
Cathepsin L/CTSL/CTSL1	Human	Cathepsin L/CTSL Protein, Recombinant
Cathepsin L/CTSL/CTSL1	Mouse	Cathepsin L/CTSL Protein, Recombinant
Cathepsin S/CTSS	Human	Cathepsin S/CTSS Protein, Recombinant
Cathepsin V/Cathepsin L2	Human	Cathepsin V/Cathepsin L2 Protein, Recombinant
Cathepsin Z/Cathepsin X	Mouse	Cathepsin Z/Cathepsin X  Protein, Recombinant

Antibody Products

Molecule	Application	Description
Human Cathepsin A/CTSA	WB	Cathepsin A/CTSA Antibody, Mouse MAb
Human Cathepsin A/CTSA	ELISA	Cathepsin A/CTSA Antibody, Mouse MAb
Human Cathepsin A/CTSA	WB, ELISA	Rabbit Polyclonal Antibody
Human Cathepsin A/CTSA	WB, ELISA	Cathepsin A/CTSA Antibody, Rabbit PAb (Antigen Affinity Purified)
Mouse Cathepsin A/CTSA	WB, ELISA	Cathepsin A/CTSA Antibody, Rabbit PAb
Mouse Cathepsin A/CTSA	WB, ELISA	Cathepsin A/CTSA Antibody, Rabbit PAb (Antigen Affinity Purified)
Human Cathepsin L/CTSL/CTSL1	WB, ELISA	Cathepsin L/CTSL Antibody, Rabbit PAb
Human Cathepsin L/CTSL/CTSL1	WB, ELISA	Cathepsin L/CTSL Antibody, Rabbit PAb (Antigen Affinity Purified)
Mouse Cathepsin Z/Cathepsin X	WB, ELISA	Rabbit Polyclonal Antibody
Mouse Cathepsin Z/Cathepsin X	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)

cDNA Clone Products

Molecule	Species	Description
Cathepsin A/CTSA	Human	Homo sapiens Cathepsin A/CTSA cDNA Clone(NM_001127695.1)
Cathepsin A/CTSA	Mouse	Mus musculus Cathepsin A/CTSA cDNA Clone
Cathepsin B/CTSB	Human	Homo sapiens Cathepsin B/CTSB cDNA Clone(NM_001908.3)
Cathepsin B/CTSB	Mouse	Mus musculus Cathepsin B/CTSB cDNA Clone
Cathepsin C/DPP1/CTSC	Human	Homo sapiens Cathepsin C/DPP1/CTSC cDNA Clone(NM_001814.4)
Cathepsin C/DPP1/CTSC	Mouse	Mus musculus Cathepsin C/DPP1/CTSC cDNA Clone
Cathepsin E/CTSE	Human	Homo sapiens Cathepsin E/CTSE cDNA Clone(NM_001910.2)
Cathepsin E/CTSE	Mouse	Mus musculus Cathepsin E/CTSE cDNA Clone
Cathepsin H/CTSH	Mouse	Mus musculus Cathepsin H/CTSH cDNA Clone
Cathepsin K/CTSK	Human	Homo sapiens Cathepsin K/CTSK cDNA Clone(NM_000396.2)
Cathepsin K/CTSK	Mouse	Mus musculus Cathepsin K/CTSK cDNA Clone
Cathepsin L/CTSL/CTSL1	Human	Homo sapiens Cathepsin L/CTSL cDNA Clone(NM_001912.4)
Cathepsin L/CTSL/CTSL1	Mouse	Mus musculus Cathepsin L/CTSL cDNA Clone
Cathepsin O/CTSO	Human	Homo sapiens Cathepsin O/CTSO cDNA Clone
Cathepsin V/Cathepsin L2	Human	Homo sapiens Cathepsin V/Cathepsin L2 cDNA Clone(NM_001333.2)
Cathepsin S/CTSS	Human	Homo sapiens Cathepsin S/CTSS cDNA Clone(NM_004079.3)
Cathepsin Z/Cathepsin X	Human	Homo sapiens Cathepsin Z/Cathepsin X cDNA Clone(NM_001336.2)
Cathepsin Z/Cathepsin X	Mouse	Mus musculus Cathepsin Z/Cathepsin X cDNA Clone

Cathepsin D Background

Cathepsin D (CTSD), a well known lysosomal aspartyl protease and belongs to the peptidase C1 family, which is a normal and major component of lysosomes, and is found in almost all cells and tissues of mammals. Its mostly described function is intracellular catabolism in lysosomal compartments, other physiological effect include hormone and antigen processing. Cathepsin D has a specificity similar to but narrower than that of pepsin A. Cathepsin D plays an important role in the degradation of proteins, the generation of bioactive proteins, antigen processing, etc. Among different role in cell physiology, a new function of this enzyme is examined. Cathepsin D is an important regulator of apoptotic pathways in cells. It acts at different stage of intrinsic and extrinsic pathway of apoptosis. In addition, CTSD secreted from human prostate carcinoma cells are responsible for the generation of angiostatin, a potent endogenous inhibitor of angiogenesis, suggesting its contribution to the prevention of tumor growth and angiogenesis-dependent growth of metastases.

Cathepsin D Related Studies

1. Fusek M, et al. (2005) Dual role of cathepsin D: ligand and protease. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 149(1): 43-50.
2. Minarowska A, et al. (2007) Regulatory role of cathepsin D in apoptosis. Folia Histochem Cytobiol. 45(3): 159-63.
3. Zaidi N, et al. (2008) Cathepsin D: a cellular roadmap. Biochem Biophys Res Commun. 376(1): 5-9.