Cathepsin C Protein (CTSC/DPP1 Protein)

Dipeptidyl-Peptidase I

Cathepsin C Products

Cathepsin C Protein, Recombinant

Molecule	Species	Description	Cat. No
Cathepsin C/DPP1/CTSC	Mouse	Cathepsin C/DPP1/CTSC Protein, Recombinant	50007-M08H

Cathepsin C cDNA Clone

Molecule	Species	Description	Cat. No
Cathepsin C/DPP1/CTSC	Human	Homo sapiens Cathepsin C/DPP1/CTSC cDNA Clone(NM_001814.4)	HG10484-M
Cathepsin C/DPP1/CTSC	Mouse	Mus musculus Cathepsin C/DPP1/CTSC cDNA Clone	MG50007-M

Cathepsin C Related Areas

Enzyme>>Protease & Regulator>>Cysteine Protease & Regulator>>Cathepsin Family>>Cathepsin C/DPP1/CTSC

Cancer>>Angiogenesis>>Cathepsin Family>>Cathepsin C/DPP1/CTSC

Immunology>>Innate Immunity>>Lysosomal Enzyme>>Cathepsin Family>>Cathepsin C/DPP1/CTSC

Cathepsin C Alternative Names

Cathepsin C, CTSC, DPP1, DPPI, CPPI, HMS, JP, JPD, PALS, PLS [Homo sapiens]

Cathepsin C, Ctsc, DPP1, DPPI, AI047818 [Mus musculus]

Cathepsin C Related Products

Protein Products

Molecule	Species	Description
Cathepsin A/CTSA	Human	Cathepsin A/CTSA Protein, Recombinant
Cathepsin A/CTSA	Mouse	Cathepsin A/CTSA Protein, Recombinant
Cathepsin B/CTSB	Human	Cathepsin B/CTSB Protein, Recombinant
Cathepsin B/CTSB	Mouse	Cathepsin B/CTSB Protein, Recombinant
Cathepsin D/CTSD	Mouse	Cathepsin D/CTSD Protein, Recombinant
Cathepsin E/CTSE	Mouse	Cathepsin E/CTSE Protein, Recombinant
Cathepsin L/CTSL/CTSL1	Human	Cathepsin L/CTSL Protein, Recombinant
Cathepsin L/CTSL/CTSL1	Mouse	Cathepsin L/CTSL Protein, Recombinant
Cathepsin S/CTSS	Human	Cathepsin S/CTSS Protein, Recombinant
Cathepsin V/Cathepsin L2	Human	Cathepsin V/Cathepsin L2 Protein, Recombinant
Cathepsin Z/Cathepsin X	Mouse	Cathepsin Z/Cathepsin X  Protein, Recombinant

Antibody Products

Molecule	Application	Description
Human Cathepsin A/CTSA	WB	Cathepsin A/CTSA Antibody, Mouse MAb
Human Cathepsin A/CTSA	ELISA	Cathepsin A/CTSA Antibody, Mouse MAb
Human Cathepsin A/CTSA	WB, ELISA	Rabbit Polyclonal Antibody
Human Cathepsin A/CTSA	WB, ELISA	Cathepsin A/CTSA Antibody, Rabbit PAb (Antigen Affinity Purified)
Mouse Cathepsin A/CTSA	WB, ELISA	Cathepsin A/CTSA Antibody, Rabbit PAb
Mouse Cathepsin A/CTSA	WB, ELISA	Cathepsin A/CTSA Antibody, Rabbit PAb (Antigen Affinity Purified)
Mouse Cathepsin D/CTSD	WB, ELISA	Rabbit Polyclonal Antibody
Mouse Cathepsin D/CTSD	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)
Human Cathepsin L/CTSL/CTSL1	WB, ELISA	Cathepsin L/CTSL Antibody, Rabbit PAb
Human Cathepsin L/CTSL/CTSL1	WB, ELISA	Cathepsin L/CTSL Antibody, Rabbit PAb (Antigen Affinity Purified)
Mouse Cathepsin Z/Cathepsin X	WB, ELISA	Rabbit Polyclonal Antibody
Mouse Cathepsin Z/Cathepsin X	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)

cDNA Clone Products

Molecule	Species	Description
Cathepsin A/CTSA	Human	Homo sapiens Cathepsin A/CTSA cDNA Clone(NM_001127695.1)
Cathepsin A/CTSA	Mouse	Mus musculus Cathepsin A/CTSA cDNA Clone
Cathepsin B/CTSB	Human	Homo sapiens Cathepsin B/CTSB cDNA Clone(NM_001908.3)
Cathepsin B/CTSB	Mouse	Mus musculus Cathepsin B/CTSB cDNA Clone
Cathepsin D/CTSD	Mouse	Mus musculus Cathepsin D/CTSD cDNA Clone
Cathepsin E/CTSE	Human	Homo sapiens Cathepsin E/CTSE cDNA Clone(NM_001910.2)
Cathepsin E/CTSE	Mouse	Mus musculus Cathepsin E/CTSE cDNA Clone
Cathepsin H/CTSH	Mouse	Mus musculus Cathepsin H/CTSH cDNA Clone
Cathepsin K/CTSK	Human	Homo sapiens Cathepsin K/CTSK cDNA Clone(NM_000396.2)
Cathepsin K/CTSK	Mouse	Mus musculus Cathepsin K/CTSK cDNA Clone
Cathepsin L/CTSL/CTSL1	Human	Homo sapiens Cathepsin L/CTSL cDNA Clone(NM_001912.4)
Cathepsin L/CTSL/CTSL1	Mouse	Mus musculus Cathepsin L/CTSL cDNA Clone
Cathepsin O/CTSO	Human	Homo sapiens Cathepsin O/CTSO cDNA Clone
Cathepsin V/Cathepsin L2	Human	Homo sapiens Cathepsin V/Cathepsin L2 cDNA Clone(NM_001333.2)
Cathepsin S/CTSS	Human	Homo sapiens Cathepsin S/CTSS cDNA Clone(NM_004079.3)
Cathepsin Z/Cathepsin X	Human	Homo sapiens Cathepsin Z/Cathepsin X cDNA Clone(NM_001336.2)
Cathepsin Z/Cathepsin X	Mouse	Mus musculus Cathepsin Z/Cathepsin X cDNA Clone

Cathepsin C Background

Cathepsins are proteases found in many types of cells conserved in all animals, which have a vital role in mammalian cellular turnover such as bone resorption. The lysosomal cysteine protease Cathepsin C (CTSC), also known as dipeptidyl peptidase I (DPPI/DPP1), activates a number of granule-associated serine proteases with pro-inflammatory and immune functions by removal of their inhibitory N-terminal dipeptides. This lysosomal exo-cysteine protease belonging to the peptidase C1 family. Active cathepsin C is found in lysosomes as a 200-kDa multimeric enzyme. Subunits constituting this assembly all arise from the proteolytic cleavage of a single precursor giving rise to three peptides: the propeptide, the alpha- and the beta-chains. It is a central coordinator for activation of many serine proteases in immune/inflammatory cells. Defects in the Cathepsin C have been shown to be a cause of Papillon-Lefevre disease, an autosomal recessive disorder characterized by palmoplantar keratosis and periodontitis. Cathepsin C plays a key role in the activation of several degradative enzymes linked to tissue destruction in inflammatory diseases. Thus, it is a therapeutic target for the treatment of a number of inflammatory and autoimmune diseases.

Cathepsin C Related Studies

1. Santilman V, et al. (2002) Importance of the propeptide in the biosynthetic maturation of rat cathepsin C. Eur J Cell Biol. 81(12): 654-63.
2. Kam CM, et al. (2004) Design and evaluation of inhibitors for dipeptidyl peptidase I (Cathepsin C). Arch Biochem Biophys. 427(2): 123-34.
3. Noack B, et al. (2008) Cathepsin C gene variants in aggressive periodontitis. J Dent Res. 87(10): 958-63.
4. Laine DI, et al. (2010) Inhibitors of cathepsin C (dipeptidyl peptidase I). Expert Opin Ther Pat. 20(4): 497-506.