Cathepsin A Protein & Antibody (CTSA)

Cathepsin A Products

Cathepsin Protein, Recombinant

Molecule	Species	Description	Cat. No
Cathepsin A/CTSA	Human	Cathepsin A/CTSA Protein, Recombinant	10482-H08H
Cathepsin A/CTSA	Mouse	Cathepsin A/CTSA Protein, Recombinant	50348-M08H

Cathepsin A Antibody

Molecule	Application	Description	Cat. No
Human Cathepsin A/CTSA	WB	Cathepsin A/CTSA Antibody, Mouse MAb	10482-MM01
Human Cathepsin A/CTSA	ELISA	Cathepsin A/CTSA Antibody, Mouse MAb	10482-MM02
Human Cathepsin A/CTSA	WB, ELISA	Rabbit Polyclonal Antibody	10482-RP01
Human Cathepsin A/CTSA	WB, ELISA	Cathepsin A/CTSA Antibody, Rabbit PAb (Antigen Affinity Purified)	10482-RP02
Mouse Cathepsin A/CTSA	WB, ELISA	Cathepsin A/CTSA Antibody, Rabbit PAb	50348-RP01
Mouse Cathepsin A/CTSA	WB, ELISA	Cathepsin A/CTSA Antibody, Rabbit PAb (Antigen Affinity Purified)	50348-RP02

Cathepsin A cDNA Clone

Molecule	Species	Description	Cat. No
Cathepsin A/CTSA	Human	Homo sapiens Cathepsin A/CTSA cDNA Clone(NM_001127695.1)	HG10482-M
Cathepsin A/CTSA	Mouse	Mus musculus Cathepsin A/CTSA cDNA Clone	MG50348-M

Cathepsin A Related Areas

Enzyme>>Protease & Regulator>>Serine Protease & Regulator>>Cathepsin A/CTSA

Cancer>>Angiogenesis>>Cathepsin Family>>Cathepsin A/CTSA

Immunology>>Innate Immunity>>Lysosomal Enzyme>>Cathepsin Family>>Cathepsin A/CTSA

Cathepsin A Alternative Names

Cathepsin A, CTSA, RP3-337O18.1, GLB2, GSL, NGBE, PPCA, PPGB [Homo sapiens]

Cathepsin A, Ctsa, RP23-61O3.6, AU019505, PPCA, Ppgb [Mus musculus]

Cathepsin A Related Products

Protein Products

Molecule	Species	Description
Cathepsin B/CTSB	Human	Cathepsin B/CTSB Protein, Recombinant
Cathepsin B/CTSB	Mouse	Cathepsin B/CTSB Protein, Recombinant
Cathepsin C/DPP1/CTSC	Mouse	Cathepsin C/DPP1/CTSC Protein, Recombinant
Cathepsin D/CTSD	Mouse	Cathepsin D/CTSD Protein, Recombinant
Cathepsin E/CTSE	Mouse	Cathepsin E/CTSE Protein, Recombinant
Cathepsin L/CTSL/CTSL1	Human	Cathepsin L/CTSL Protein, Recombinant
Cathepsin L/CTSL/CTSL1	Mouse	Cathepsin L/CTSL Protein, Recombinant
Cathepsin S/CTSS	Human	Cathepsin S/CTSS Protein, Recombinant
Cathepsin V/Cathepsin L2	Human	Cathepsin V/Cathepsin L2 Protein, Recombinant
Cathepsin Z/Cathepsin X	Mouse	Cathepsin Z/Cathepsin X  Protein, Recombinant

Antibody Products

Molecule	Application	Description
Mouse Cathepsin D/CTSD	WB, ELISA	Rabbit Polyclonal Antibody
Mouse Cathepsin D/CTSD	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)
Human Cathepsin L/CTSL/CTSL1	WB, ELISA	Cathepsin L/CTSL Antibody, Rabbit PAb
Human Cathepsin L/CTSL/CTSL1	WB, ELISA	Cathepsin L/CTSL Antibody, Rabbit PAb (Antigen Affinity Purified)
Mouse Cathepsin Z/Cathepsin X	WB, ELISA	Rabbit Polyclonal Antibody
Mouse Cathepsin Z/Cathepsin X	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)

cDNA Clone Products

Molecule	Species	Description
Cathepsin B/CTSB	Human	Homo sapiens Cathepsin B/CTSB cDNA Clone(NM_001908.3)
Cathepsin B/CTSB	Mouse	Mus musculus Cathepsin B/CTSB cDNA Clone
Cathepsin C/DPP1/CTSC	Human	Homo sapiens Cathepsin C/DPP1/CTSC cDNA Clone(NM_001814.4)
Cathepsin C/DPP1/CTSC	Mouse	Mus musculus Cathepsin C/DPP1/CTSC cDNA Clone
Cathepsin D/CTSD	Mouse	Mus musculus Cathepsin D/CTSD cDNA Clone
Cathepsin E/CTSE	Human	Homo sapiens Cathepsin E/CTSE cDNA Clone(NM_001910.2)
Cathepsin E/CTSE	Mouse	Mus musculus Cathepsin E/CTSE cDNA Clone
Cathepsin H/CTSH	Mouse	Mus musculus Cathepsin H/CTSH cDNA Clone
Cathepsin K/CTSK	Human	Homo sapiens Cathepsin K/CTSK cDNA Clone(NM_000396.2)
Cathepsin K/CTSK	Mouse	Mus musculus Cathepsin K/CTSK cDNA Clone
Cathepsin L/CTSL/CTSL1	Human	Homo sapiens Cathepsin L/CTSL cDNA Clone(NM_001912.4)
Cathepsin L/CTSL/CTSL1	Mouse	Mus musculus Cathepsin L/CTSL cDNA Clone
Cathepsin O/CTSO	Human	Homo sapiens Cathepsin O/CTSO cDNA Clone
Cathepsin V/Cathepsin L2	Human	Homo sapiens Cathepsin V/Cathepsin L2 cDNA Clone(NM_001333.2)
Cathepsin S/CTSS	Human	Homo sapiens Cathepsin S/CTSS cDNA Clone(NM_004079.3)
Cathepsin Z/Cathepsin X	Human	Homo sapiens Cathepsin Z/Cathepsin X cDNA Clone(NM_001336.2)
Cathepsin Z/Cathepsin X	Mouse	Mus musculus Cathepsin Z/Cathepsin X cDNA Clone

Cathepsin A Background

Lysosomal carboxypeptidase, cathepsin A (protective protein, CathA), is a component of the lysosomal multienzyme complex along with beta-galactosidase (GAL) and sialidase Neu1, where it activates Neu1 and protects GAL and Neu1 against the rapid proteolytic degradation. Cathepsin A is a multicatalytic enzyme with deamidase and esterase in addition to carboxypeptidase activities. It was recently identified in human platelets as deamidase. In vitro, it hydrolyzes a variety of bioactive peptide hormones including tachykinins, suggesting that extralysosomal cathepsin A plays a role in regulation of bioactive peptide functions. It is a member of the alpha/beta hydrolase fold family and has been suggested to share a common ancestral relationship with other alpha/beta hydrolase fold enzymes, such as cholinesterases. Cathepsin A defects are linked to multiple forms of Galactosialidosis with a combined secondary deficiency of beta-galactosidase and neuraminidase. Cathepsin A is a key molecule in the onset of galactosialidosis and also highlight the therapeutic acts in vivo as an endothelin-1-inactivating enzyme and strongly confirm a crucial role of this enzyme in effective elastic fiber formation.

Cathepsin A Related Studies

1. Hiraiwa M. (1999) Cathepsin A/protective protein: an unusual lysosomal multifunctional protein. Cell Mol Life Sci. 56(11-12): 894-907.
2. Yoshida T, et al. (2006) Comparative analysis of binding energy of chymostatin with human cathepsin A and its homologous proteins by molecular orbital calculation. J Chem Inf Model. 46(5): 2093-103.
3. Seyrantepe V, et al. (2008) Enzymatic activity of lysosomal carboxypeptidase (cathepsin) A is required for proper elastic fiber formation and inactivation of endothelin-1. Circulation. 117(15): 1973-81.