All Cathepsin A reagents are produced in house and quality controlled, including 8 Cathepsin A Antibody, 28 Cathepsin A Gene, 1 Cathepsin A IPKit, 2 Cathepsin A Lysate, 2 Cathepsin A Protein, 2 Cathepsin A qPCR. All Cathepsin A reagents are ready to use.
Recombinant Cathepsin A proteins are expressed by HEK293 Cells with fusion tags as C-His.
Cathepsin Aantibodies are validated with different applications, which are ELISA, WB, IP, ICC/IF, IF.
Cathepsin AcDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each Cathepsin A of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
Lysosomal carboxypeptidase, cathepsin A (protective protein, CathA), is a component of the lysosomal multienzyme complex along with beta-galactosidase (GAL) and sialidase Neu1, where it activates Neu1 and protects GAL and Neu1 against the rapid proteolytic degradation. Cathepsin A is a multicatalytic enzyme with deamidase and esterase in addition to carboxypeptidase activities. It was recently identified in human platelets as deamidase. In vitro, it hydrolyzes a variety of bioactive peptide hormones including tachykinins, suggesting that extralysosomal cathepsin A plays a role in regulation of bioactive peptide functions. It is a member of the alpha/beta hydrolase fold family and has been suggested to share a common ancestral relationship with other alpha/beta hydrolase fold enzymes, such as cholinesterases. Cathepsin A defects are linked to multiple forms of Galactosialidosis with a combined secondary deficiency of beta-galactosidase and neuraminidase. Cathepsin A is a key molecule in the onset of galactosialidosis and also highlight the therapeutic acts in vivo as an endothelin-1-inactivating enzyme and strongly confirm a crucial role of this enzyme in effective elastic fiber formation.