Anti-Cathepsin A Antibody


Application | Dilution | Notes |
---|---|---|
ELISA | 1:1000-1:2000 |
**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********
Lysosomal carboxypeptidase, cathepsin A (protective protein, CathA), is a component of the lysosomal multienzyme complex along with beta-galactosidase (GAL) and sialidase Neu1, where it activates Neu1 and protects GAL and Neu1 against the rapid proteolytic degradation. Cathepsin A is a multicatalytic enzyme with deamidase and esterase in addition to carboxypeptidase activities. It was recently identified in human platelets as deamidase. In vitro, it hydrolyzes a variety of bioactive peptide hormones including tachykinins, suggesting that extralysosomal cathepsin A plays a role in regulation of bioactive peptide functions. It is a member of the alpha/beta hydrolase fold family and has been suggested to share a common ancestral relationship with other alpha/beta hydrolase fold enzymes, such as cholinesterases. Cathepsin A defects are linked to multiple forms of Galactosialidosis with a combined secondary deficiency of beta-galactosidase and neuraminidase. Cathepsin A is a key molecule in the onset of galactosialidosis and also highlight the therapeutic acts in vivo as an endothelin-1-inactivating enzyme and strongly confirm a crucial role of this enzyme in effective elastic fiber formation.
Product Description | Host | Clonality | Application | Catalog# (PDF) |
---|---|---|---|---|
Anti-Cathepsin A Antibody | Rabbit | Monoclonal | ELISA | 50348-R108 |
Anti-Cathepsin A Antibody | Rabbit | Polyclonal | ELISA | 50348-RP02 |
Anti-Cathepsin A Antibody | Rabbit | Polyclonal | ELISA | 50348-RP01 |
Anti-Cathepsin A Antibody | Rabbit | Polyclonal | WB,ELISA,IP | 50348-T52 |
Anti-Cathepsin A Antibody | Rabbit | Monoclonal | ELISA,ICC/IF,IF | 10482-R104 |
Anti-Cathepsin A Antibody | Rabbit | Polyclonal | ELISA | 10482-RP02 |
Anti-Cathepsin A Antibody | Rabbit | Polyclonal | ELISA | 10482-RP01 |