Anti-Cathepsin A Antibody

Cat: 10482-MM02
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Anti-Cathepsin A Antibody (Mouse Monoclonal antibody) General Information
Product name
Anti-Cathepsin A Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human Cathepsin A
Immunogen
Recombinant Human CTSA protein (Catalog#10482-H08H)
Preparation
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CTSA (rh CTSA; Catalog#10482-H08H; NP_001121167.1; Met 1-Tyr 480). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Source
Monoclonal Mouse IgG1 Clone #7F6E7E5
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-Cathepsin A Antibody (Mouse Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-Cathepsin A Antibody Alternative Names
Anti-GLB2 Antibody;Anti-GSL Antibody;Anti-NGBE Antibody;Anti-PPCA Antibody;Anti-PPGB Antibody
Cathepsin A Background Information

Lysosomal carboxypeptidase, cathepsin A (protective protein, CathA), is a component of the lysosomal multienzyme complex along with beta-galactosidase (GAL) and sialidase Neu1, where it activates Neu1 and protects GAL and Neu1 against the rapid proteolytic degradation. Cathepsin A is a multicatalytic enzyme with deamidase and esterase in addition to carboxypeptidase activities. It was recently identified in human platelets as deamidase. In vitro, it hydrolyzes a variety of bioactive peptide hormones including tachykinins, suggesting that extralysosomal cathepsin A plays a role in regulation of bioactive peptide functions. It is a member of the alpha/beta hydrolase fold family and has been suggested to share a common ancestral relationship with other alpha/beta hydrolase fold enzymes, such as cholinesterases. Cathepsin A defects are linked to multiple forms of Galactosialidosis with a combined secondary deficiency of beta-galactosidase and neuraminidase. Cathepsin A is a key molecule in the onset of galactosialidosis and also highlight the therapeutic acts in vivo as an endothelin-1-inactivating enzyme and strongly confirm a crucial role of this enzyme in effective elastic fiber formation.

Full Name
cathepsin A
Research Areas
References
  • Hiraiwa M. (1999) Cathepsin A/protective protein: an unusual lysosomal multifunctional protein. Cell Mol Life Sci. 56(11-12): 894-907.
  • Yoshida T, et al. (2006) Comparative analysis of binding energy of chymostatin with human cathepsin A and its homologous proteins by molecular orbital calculation. J Chem Inf Model. 46(5): 2093-103.
  • Seyrantepe V, et al. (2008) Enzymatic activity of lysosomal carboxypeptidase (cathepsin) A is required for proper elastic fiber formation and inactivation of endothelin-1. Circulation. 117(15): 1973-81.
    • Product Description Host Clonality Application Catalog# (PDF)
    Anti-Cathepsin A Antibody Rabbit Monoclonal ELISA 50348-R108
    Anti-Cathepsin A Antibody Rabbit Polyclonal ELISA 50348-RP02
    Anti-Cathepsin A Antibody Rabbit Polyclonal ELISA 50348-RP01
    Anti-Cathepsin A Antibody Rabbit Polyclonal WB,ELISA,IP 50348-T52
    Anti-Cathepsin A Antibody Rabbit Monoclonal ELISA,ICC/IF,IF 10482-R104
    Anti-Cathepsin A Antibody Rabbit Polyclonal ELISA 10482-RP02
    Anti-Cathepsin A Antibody Rabbit Polyclonal ELISA 10482-RP01
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