Caspase-14 (CASP14)

Caspase 14 is a member of the caspase family. Caspases are a kind of cysteine proteinase consisting of a prodomain plus large and small catalytic subunits, that play a central role in cell apoptosis. Caspase 14 possesses an unusually short prodomain and is highly expressed in embryonic tissues but absent from most of the adult tissues except for the skin, which suggests a role in ontogenesis and skin physiology. Unlike the other short prodomain caspases(caspase-3, caspase-6, and caspase-7), Caspase 14 was not processed by multiple death stimuli including activation of members of the tumor necrosis factor receptor family and expression of proapaptotic members of the bcl-2 family. Caspase 14 has been described to be processed and activated by anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo. The expression and processing of this caspase may take part in keratinocyte terminal differentiation, which is essential for the skin barrier.

Caspase-14 (CASP14) Related Areas

Enzyme>>Protease & Regulator>>Cysteine Protease & Regulator>>Caspase>>Caspase-14/CASP14

Caspase-14 (CASP14) Alternative Names

Caspase-14, CASP14, CASP-14, MGC119078, MGC119079 [Homo sapiens]

Caspase-14, Casp14, CASP-14, MGC123948, MGC123949, MICE, mini-ICE [Mus musculus]

Summaries for Caspase-14 (CASP14)

Entrez Gene summary for Caspase-14 (CASP14):

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This caspase has been shown to be processed and activated by caspase 8 and caspase 10 in vitro, and by anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo. The expression and processing of this caspase may be involved in keratinocyte terminal differentiation, which is important for the formation of the skin barrier.

OMIM - description for Caspase-14 (CASP14):

CASP14 belongs to the evolutionarily conserved caspase family. Caspases are cysteinyl aspartate-specific proteinases, many of which play a central role in apoptosis (Van de Craen et al., 1998). See CASP1 (147678) for additional background information on caspases.

Wikipedia summary for Caspase-14 (CASP14):

Caspase 14 is an enzyme that in humans is encoded by the CASP14 gene.The CASP14 gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This caspase has been shown to be processed and activated by caspase 8 and caspase 10 in vitro, and by anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo. The expression and processing of this caspase may be involved in keratinocyte terminal differentiation, which is important for the formation of the skin barrier

Human Caspase-14 (CASP14) Protein General Information

 

• Protein names: Recommended name: Caspase-14 Short name=CASP-14
• Sequence length: 242 AA.
• Sequence similarities: Belongs to the peptidase C14A family.
• Subunit structure: Complex of unprocessed caspase-14 and processed 19 kDa (p19) and 10 kDa (p10) subunits.
• Subcellular location: Cytoplasm. Nucleus
• Tissue specificity: Expressed in keratinocytes of adult skin suprabasal layers (from spinous layers to the stratum granulosum and stratum corneum) (at protein level). Expressed in keratinocytes of hair shaft and sebaceous glands (at protein level). In psoriatic skin only expressed at very low levels.

General information above from UniProt

Function for Caspase-14 (CASP14) Protein

UniProtKB:

Believed to be a non-apoptotic caspase which is involved in epidermal differentiation. Seems to play a role in keratinocyte differentiation and cornification. Probably regulates maturation of the epidermis by proteolytically processing filaggrin

Genatlas:

• Caspase-14 (CASP14) is caspase family of cysteinyl-aspartate specific proteases
• Caspase-14 (CASP14) is involved in the death receptor and granzyme B apoptotic pathways
• Caspase-14 (CASP14) may function as a downstream signal transducer of cell death
• Caspase-14 (CASP14) is important for the formation of the skin barrier
• non-apoptotic caspase involved in keratinocyte differentiation and cornification
• Caspase-14 (CASP14) protease involved in skin barrier formation, and specifically expressed in epidermal keratinocytes
• anti-apoptotic protein targeting apoptosis-inducing factor and increases cisplatin resistance in lung adenocarcinomas cells

Homology for human Caspase-14 (CASP14)

• homolog to rattus Casp14 (73pc)
• homolog to murine Casp14 (75.1pc)