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Human CASP7 cDNA Clone Product Information
NCBI RefSeq:
RefSeq ORF Size:
cDNA Description:
Gene Synonym:
Species:
Vector:
Restriction Site:
Tag Sequence:
Sequence Description:
Shipping_carrier:
Storage:
Human CASP7 Gene Plasmid Map
Human Caspase-7 transcript variant alpha Gene cDNA Clone (full-length ORF Clone), expression ready, untagged
pCMV/hygro Vector Information
 
Vector Name pCMV/hygro
Vector Size 5657bp
Vector Type Mammalian Expression Vector
Expression Method Constiutive ,Stable / Transient
Promoter CMV
Antibiotic Resistance Ampicillin
Selection In Mammalian Cells Hygromycin
Protein Tag None
Sequencing Primer Forward:T7(TAATACGACTCACTATAGGG)
Reverse:BGH(TAGAAGGCACAGTCGAGG)


Schematic of pCMV/hygro Multiple Cloning Sites
Human Caspase-7/MCH3 transcript variant alpha Gene ORF cDNA clone expression plasmid, C-GFPSpark tagHG10049-ACG$225
Human Caspase-7/MCH3 transcript variant alpha Gene ORF cDNA clone expression plasmid, C-OFPSpark tagHG10049-ACR$225
Human Caspase-7/MCH3 transcript variant alpha Gene ORF cDNA clone expression plasmid, N-GFPSpark tagHG10049-ANG$225
Human Caspase-7/MCH3 transcript variant alpha Gene ORF cDNA clone expression plasmid, N-OFPSpark tagHG10049-ANR$225
Human Caspase-7/MCH3 transcript variant alpha Gene ORF cDNA clone expression plasmid, C-Flag tagHG10049-CF$195
Human Caspase-7/MCH3 transcript variant alpha Gene ORF cDNA clone expression plasmid, C-His tagHG10049-CH$195
Human Caspase-7/MCH3 transcript variant alpha Gene ORF cDNA clone expression plasmid, C-Myc tagHG10049-CM$195
Human Caspase-7/MCH3 transcript variant alpha Gene ORF cDNA clone expression plasmid, C-HA tagHG10049-CY$195
Human Caspase-7/MCH3 transcript variant alpha Gene ORF cDNA clone in cloning vectorHG10049-M$75
Human Caspase-7/MCH3 transcript variant alpha Gene ORF cDNA clone expression plasmid, C-Flag tagHG10049-M-F$195
Human Caspase-7/MCH3 transcript variant alpha Gene ORF cDNA clone expression plasmid, N-Flag tagHG10049-NF$195
Human Caspase-7/MCH3 transcript variant alpha Gene ORF cDNA clone expression plasmid, N-His tagHG10049-NH$195
Human Caspase-7/MCH3 transcript variant alpha Gene ORF cDNA clone expression plasmid, N-Myc tagHG10049-NM$195
Human Caspase-7/MCH3 transcript variant alpha Gene ORF cDNA clone expression plasmid, N-HA tagHG10049-NY$195
Human Caspase-7/MCH3 transcript variant alpha Gene ORF cDNA clone expression plasmidHG10049-UT$195
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Background

Caspase 7, also known as caspase-7 and MCH3, belongs to the cysteine-aspartic acid protease (caspase) family. Caspases play a role in the signal transduction pathways of apoptosis, necrosis and inflammation. There are two major classes of caspases: initiators and effectors. The initiator isoforms (caspases-1,-4,-5,-8,-9,-10,-11,-12) are activated by, and interact with, upstream adaptor molecules through protein-protein interaction domains known as CARD and DED. Effector caspases (-3,-6,-7) are responsible for cleaving downstream substrates and are sometimes referred to as the executioner caspases. Caspase 7 exists in lung, skeletal muscle, liver, kidney, spleen and heart, and moderately in testis. Caspase 7 cannot be detected in the brain. Caspase 7 functions in the activation cascade of caspases responsible for apoptosis execution. It cleaves and activates sterol regulatory element binding proteins (SREBPs). It proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp- -Gly-217' bond. Overexpression promotes programmed cell death.

References
  • Riedl S J, et al. (2001) Structural basis for the inhibition of caspase-3 by XIAP. Cell. 104(5):791-800.
  • Roy N, et al. (1997) The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases. EMBO J. 16(23):6914-25.
  • Deveraux Q L, et al. (1997) X-linked IAP is a direct inhibitor of cell-death proteases. Nature. 388(6639): 300-4.
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    • Human Caspase-7 transcript variant alpha Gene cDNA Clone (full-length ORF Clone), expression ready, untagged
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