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Caspase-14/CASP14  Protein, Antibody, ELISA Kit, cDNA Clone

Description: Active  
Expression host: E. coli  
50 µg 
20 µg 
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Caspase-14/CASP14 Related Area

Caspase-14/CASP14 Related Pathways

Caspase-14/CASP14 Summary & Protein Information

Caspase-14/CASP14 Background

Gene Summary: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This caspase has been shown to be processed and activated by caspase 8 and caspase 10 in vitro, and by anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo. The expression and processing of this caspase may be involved in keratinocyte terminal differentiation, which is important for the formation of the skin barrier.
General information above from NCBI
Subunit structure: Complex of unprocessed caspase-14 and processed 19 kDa (p19) and 10 kDa (p10) subunits. {ECO:0000269|PubMed:12200134}.
Subcellular location: Cytoplasm. Nucleus.
Tissue specificity: Expressed in keratinocytes of adult skin suprabasal layers (from spinous layers to the stratum granulosum and stratum corneum) (at protein level). Expressed in keratinocytes of hair shaft and sebaceous glands (at protein level). In psoriatic skin only expressed at very low levels. {ECO:0000269|PubMed:11175259}.
Induction: In undifferentiated keratinocytes under postconfluency growth conditions (in vitro). {ECO:0000269|PubMed:11175259}.
Sequence similarity: Belongs to the peptidase C14A family. {ECO:0000305}.
General information above from UniProt

Caspase 14 is a member of the caspase family. Caspases are a kind of cysteine proteinase consisting of a prodomain plus large and small catalytic subunits, that play a central role in cell apoptosis. Caspase 14 possesses an unusually short prodomain and is highly expressed in embryonic tissues but absent from most of the adult tissues except for the skin, which suggests a role in ontogenesis and skin physiology. Unlike the other short prodomain caspases(caspase-3, caspase-6, and caspase-7), Caspase 14 was not processed by multiple death stimuli including activation of members of the tumor necrosis factor receptor family and expression of proapaptotic members of the bcl-2 family. Caspase 14 has been described to be processed and activated by anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo. The expression and processing of this caspase may take part in keratinocyte terminal differentiation, which is essential for the skin barrier.

Caspase-14/CASP14 Alternative Name

CASP14,MGC119079,CASP-14,Caspase-14,MGC119078, [human]
Casp14,CASP-14,MGC123948,MGC123949,MICE,mini-ICE,Caspase-14, [mouse]
MICE,mini-ICE, [mus-musculus]

Caspase-14/CASP14 Related Studies

  • Hu SM, et al. (1998) Caspase-14 is a novel developmentally regulated protease. The journal of biological chemistry. 273: 29648-53.
  • Marc Van De Craen, et al. (1998) Identification of a new caspase homologue: caspase-14. Cell death differ. 5(10): 838-46.