Caspase-14 / CASP14 Protein & Antibody

Caspase-14 / CASP14 Products

Caspase-14 / CASP14 Protein, Recombinant

Molecule	Species	Description	Cat. No
Caspase-14/CASP14	Human	Caspase-14/CASP14 Protein, Recombinant	11856-H07E

Caspase-14 / CASP14 Antibody

Molecule	Application	Description	Cat. No
Human Caspase-14/CASP14	WB,ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	11856-RP02
Human Caspase-14/CASP14	WB,ELISA	Caspase-14 / CASP14 Antibody	11856-MM01

Caspase-14 / CASP14 Related Areas

Enzyme>>Protease & Regulator>>Cysteine Protease & Regulator>>Caspase>>Caspase-14/CASP14

Caspase-14 / CASP14 Alternative Names

Caspase-14, CASP14, CASP-14, MGC119078, MGC119079 [Homo sapiens]

Caspase-14, Casp14, CASP-14, MGC123948, MGC123949, MICE, mini-ICE [Mus musculus]

Caspase-14 / CASP14 Background

Caspase 14 is a member of the caspase family. Caspases are a kind of cysteine proteinase consisting of a prodomain plus large and small catalytic subunits, that play a central role in cell apoptosis. Caspase 14 possesses an unusually short prodomain and is highly expressed in embryonic tissues but absent from most of the adult tissues except for the skin, which suggests a role in ontogenesis and skin physiology. Unlike the other short prodomain caspases(caspase-3, caspase-6, and caspase-7), Caspase 14 was not processed by multiple death stimuli including activation of members of the tumor necrosis factor receptor family and expression of proapaptotic members of the bcl-2 family. Caspase 14 has been described to be processed and activated by anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo. The expression and processing of this caspase may take part in keratinocyte terminal differentiation, which is essential for the skin barrier.

Caspase-14 / CASP14 Related Studies

1. Hu SM, et al. (1998) Caspase-14 is a novel developmentally regulated protease. The journal of biological chemistry. 273: 29648-53.
2. Marc Van De Craen, et al. (1998) Identification of a new caspase homologue: caspase-14. Cell death differ. 5(10): 838-46.