Anti-Caspase-14 Antibody

Cat: 11856-MM01
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All Caspase-14 Reagents
Anti-Caspase-14 Antibody (Mouse Monoclonal antibody) General Information
Product name
Anti-Caspase-14 Antibody
Validated applications
Species reactivity
Reacts with: Human
Human Caspase-14
No cross-reactivity in ELISA with E.coli cell lysate
Recombinant Human Caspase-14 / CASP14 protein (Catalog#11856-H07E)
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Caspase-14 / CASP14 (rh Caspase-14 / CASP14; Catalog#11856-H07E; NP_036246.1; Ser 2-Gln 242). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Monoclonal Mouse IgG2b Clone #1G6A2
Protein A
0.2 μm filtered solution in PBS with 5% trehalose
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-Caspase-14 Antibody (Mouse Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Caspase-14 Background Information

Caspase 14 is a member of the caspase family. Caspases are a kind of cysteine proteinase consisting of a prodomain plus large and small catalytic subunits, that play a central role in cell apoptosis. Caspase 14 possesses an unusually short prodomain and is highly expressed in embryonic tissues but absent from most of the adult tissues except for the skin, which suggests a role in ontogenesis and skin physiology. Unlike the other short prodomain caspases(caspase-3, caspase-6, and caspase-7), Caspase 14 was not processed by multiple death stimuli including activation of members of the tumor necrosis factor receptor family and expression of proapaptotic members of the bcl-2 family. Caspase 14 has been described to be processed and activated by anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo. The expression and processing of this caspase may take part in keratinocyte terminal differentiation, which is essential for the skin barrier.

Full Name
caspase 14, apoptosis-related cysteine peptidase
  • Hu SM, et al. (1998) Caspase-14 is a novel developmentally regulated protease. The journal of biological chemistry. 273: 29648-53.
  • Marc Van De Craen, et al. (1998) Identification of a new caspase homologue: caspase-14. Cell death differ. 5(10): 838-46.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-Caspase-14 Antibody (FITC) Mouse Monoclonal FCM 11856-MM05-F
    Anti-Caspase-14 Antibody Rabbit Monoclonal IHC-P,ICC/IF,IF 11856-R101
    Anti-Caspase-14 Antibody Rabbit Monoclonal IHC-P 11856-R001
    Anti-Caspase-14 Antibody Rabbit Polyclonal ELISA 11856-RP01
    Anti-Caspase-14 Antibody Rabbit Polyclonal ELISA 11856-T16
    Anti-Caspase-14 Antibody Mouse Monoclonal ELISA,FCM,ICC/IF,IF 11856-MM05
    Anti-Caspase-14 Antibody Mouse Monoclonal IHC-P 11856-MM09
    Anti-Caspase-14 Antibody Mouse Monoclonal IHC-P 11856-MM20
    Anti-Caspase-14 Antibody (FITC) Rabbit Monoclonal FCM 11856-R006-F
    Anti-Caspase-14 Antibody (PE) Rabbit Monoclonal FCM 11856-R006-P
    Anti-Caspase-14 Antibody Rabbit Monoclonal ELISA,FCM 11856-R145
    Anti-Caspase-14 Antibody Rabbit Polyclonal ELISA,IHC-P 11856-RP02
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