Cardiogenesis

Sino Biological offers a comprehensive set of tools for the study of cardiogenesis, including recombinant proteins, antibodies (rabbit monoclonal antibodies, mouse monoclonal antibodies, and rabbit polyclonal antibodies), ELISA kits, and ORF cDNA clones.

Cardiogenesis Background

The heart is the first organ to form in vertebrates, and it arises through a complex series of morphogenetic interactions involving cells from several embryonic origins. Progenitor cells within the anterior lateral plate mesoderm become committed to a cardiogenic fate soon after gastrulation in response to an inducing signal that is thought to emanate from the adjacent endoderm. Bone morphogenetic proteins (BMPs), fibroblast growth factors (FGFs), and Wnts appear to be critical for this step. However, more evidence is needed, and specific signaling molecules responsible for cardiogenesis remain to be identified. Some transcription factors have been identified to be critical for cardiogenesis, such as Tbx1 and Islet1, which are necessary for development of the cardiac outflow tract (conotruncus), Hand1 and Hand2, which may play a role in the inner curvature remodeling, TFAP2b, mutation of which results in persistent patency of the ductus arteriosus, and NFATc, which is expressed specifically during cardiac valve formation. In addition, TGF-beta family members, Smad proteins, and the Notch signaling pathway have also been indicated to be involved in cardiogenesis. Recent advances in our understanding of the biological complexity of cardiogenesis are beginning to point to novel approaches for regenerative cardiovascular medicine.

Cardiogenesis Related Studies

1. Srivastava D. (2006) Genetic regulation of cardiogenesis and congenital heart disease. Annu Rev Pathol. 1:9-213.
2. Chien KR, et al. (2008) Cardiogenesis and the complex biology of regenerative cardiovascular medicine. Science. 322(5907):1494-7.
3. Bu L, et al. (2009) Human ISL1 heart progenitors generate diverse multipotent cardiovascular cell lineages. Nature. 460(7251):113-7.
4. Armiñán A, et al. (2010) Cardiac transcription factors driven lineage-specification of adult stem cells. J Cardiovasc Transl Res. 3(1):61-5.
5. Chiriac A, et al. (2010) Cardiogenic induction of pluripotent stem cells streamlined through a conserved SDF-1/VEGF/BMP2 integrated network. PLoS One. 5(4):e9943.