Carboxypeptidase B1

Carboxypeptidase B is a carboxypeptidase that preferentially acts upon basic amino acids, such as arginine and lysine.

Carboxypeptidase B1 Related Areas

Cancer>>Angiogenesis>>Other Proteases & Related Molecules in Angiogenesis>>Carboxypeptidase B1/CPB1

Enzyme>>Protease & Regulator>>Carboxypeptidase & Regulator>>Carboxypeptidase B1/CPB1

Carboxypeptidase B1 Alternative Names

Carboxypeptidase B1, CPB1, CPB, DKFZp779K1333, PASP, PCPB [Homo sapiens]

Carboxypeptidase B1, Cpb1, 0910001A18Rik, 1810063F02Rik, 2210008M23Rik, AI504870 [Mus musculus]

Summaries for Carboxypeptidase B1

Entrez Gene summary for Carboxypeptidase B1:

Three different procarboxypeptidases A and two different procarboxypeptidases B have been isolated. The B1 and B2 forms differ from each other mainly in isoelectric point. Carboxypeptidase B1 is a highly tissue-specific protein and is a useful serum marker for acute pancreatitis and dysfunction of pancreatic transplants. It is not elevated in pancreatic carcinoma.

OMIM - description for Carboxypeptidase B1:

Yamamoto et al. (1992) noted that pancreatic carboxypeptidase B was originally described and characterized as pancreas-specific protein (PSAP), a useful serum marker for acute pancreatitis and dysfunction of pancreatic transplants. It is not elevated in pancreatic carcinoma. The protein constitutes about 2% of total pancreatic cytosolic proteins

Wikipedia summary for Carboxypeptidase B1:

Carboxypeptidase B is a carboxypeptidase that preferentially acts upon basic amino acids, such as arginine and lysine.

Human Carboxypeptidase B1 Protein General Information

 

• Protein names: Recommended name: Carboxypeptidase B
• Sequence length: 417 AA.
• Domain: Signal
• Sequence similarities: Belongs to the peptidase M14 family.
• Catalytic activity: Preferential release of a C-terminal lysine or arginine amino acid.
• Subcellular location: Secreted.
• Tissue specificity: Pancreas.
• Cofactor: Binds 1 zinc ion per subunit.

General information above from UniProt

Function for Carboxypeptidase B1 Protein

UniProtKB:

Genatlas:

• Carboxypeptidase B1 modulates the plasminogen system both in the matrix and on the cell surface, thus leading to the inhibition of endothelial cell movement and tube formation
• Carboxypeptidase B1 cleaves off basic C-terminal residues and secreted as inactive zymogens

Homology for human Carboxypeptidase B1

• homolog to C.elegans y59c2a.1