Carboxypeptidase A2

Carboxypeptidase A2 is an enzyme that in humans is encoded by the CPA2 gene. Three different forms of human pancreatic procarboxypeptidase A have been isolated. The A1 and A2 forms are monomeric proteins with different biochemical properties. The A2 form of pancreatic procarboxypeptidase acts on aromatic C-terminal residues

Carboxypeptidase A2 Related Areas

Enzyme>>Protease & Regulator>>Carboxypeptidase & Regulator>>Carboxypeptidase A2/CPA2

Carboxypeptidase A2 Alternative Names

Carboxypeptidase A2, CPA2

Summaries for Carboxypeptidase A2

Entrez Gene summary for Carboxypeptidase A2:

Three different forms of human pancreatic procarboxypeptidase A have been isolated. The encoded protein represents the A2 form, which is a monomeric protein with different biochemical properties from the A1 and A3 forms. The A2 form of pancreatic procarboxypeptidase acts on aromatic C-terminal residues and is a secreted protein.

OMIM - description for Carboxypeptidase A2:

Catasus et al. (1995) obtained the cDNA by screening a human pancreatic expression library with antibodies to the protein. The full-length cDNA encodes a deduced 417-amino acid protein, which includes a short leader sequence and a 94-amino acid long activation segment. The human CPA2 protein shares 89% similarity with the rat CPA2 protein (Gardell et al., 1988) and 64% similarity with human CPA1 (114850). The A2 form of pancreatic procarboxypeptidase acts on aromatic C-terminal residues, in contrast to the A1 form, which shows a preference for the aliphatic C-terminal residues of peptide substrates. See also pancreatic carboxypeptidase B (114852).

Wikipedia summary for Carboxypeptidase A2:

Carboxypeptidase A2 is an enzyme that in humans is encoded by the CPA2 gene. Three different forms of human pancreatic procarboxypeptidase A have been isolated. The A1 and A2 forms are monomeric proteins with different biochemical properties. The A2 form of pancreatic procarboxypeptidase acts on aromatic C-terminal residues

Human Carboxypeptidase A2 Protein General Information

 

• Protein names: Recommended name: Carboxypeptidase A2
• Sequence length: 419 AA.
• Catalytic activity: Similar to that of carboxypeptidase A (EC 3.4.17.1), but with a preference for bulkier C-terminal residues.
• Sequence similarities: Belongs to the peptidase M14 family.
• Cofactor: Binds 1 zinc ion per subunit.
• Subcellular location: Secreted.

General information above from UniProt

Function for Carboxypeptidase A2 Protein

UniProtKB:

Genatlas:

• Carboxypeptidase A2 cleaves substrates with C terminal hydrophobic residues