Anti-Carboxypeptidase M Antibody

Cat: 11228-RP01
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Anti-Carboxypeptidase M Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-Carboxypeptidase M Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human Carboxypeptidase M
Immunogen
Recombinant Human CPM protein (Catalog#11228-H08H)
Preparation
Produced in rabbits immunized with purified, recombinant Human CPM (rh CPM; Catalog#11228-H08H; NP_938079.1; Met 1-His 422). Total IgG was purified by Protein A affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-Carboxypeptidase M Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Carboxypeptidase M Background Information

Carboxypeptidase M, also known as CPM, is a membrane-bound arginine/lysine carboxypeptidase which is a member of the carboxypeptidases family. These enzymes remove C-terminal amino acids from peptides and proteins and exert roles in the physiological processes of blood coagulation/fibrinolysis, inflammation, food digestion and pro-hormone and neuropeptide processing. Among the carboxypeptidases CPM is of particular importance because of its constitutive expression in an active form at the surface of specialized cells and tissues in the human body. CPM in the brain appears to be membrane-bound via a phosphatidylinositol glycan anchor. CPM is widely distributed in a variety of tissues and cells. The amino acid sequence of CPM indicated that the C-terminal hydrophobic region might be a signal for membrane attachment via a glycosylphosphatidylinositol (GPI) anchor. CPM is involved in peptide metabolism on both the cell surface and in extracellular fluids. CPM functions not only as a protease but also as a binding partner in cell-surface protein-protein interactions.

Full Name
carboxypeptidase M
References
  • Deddish PA. et al., 1990, J Biol Chem. 265 (25): 15083-9.
  • Nagae A. et al., 1992, J Neurochem. 59 (6): 2201-12.
  • Skidgel RA. et al., 1996, Immunopharmacology. 32 (1-3): 48-52.
  • Deiteren K. et al., 2009, Clin Chim Acta. 399 (1-2): 24-39.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-Carboxypeptidase M Antibody Rabbit Monoclonal ELISA 50990-R085
    Anti-Carboxypeptidase M Antibody Rabbit Polyclonal ELISA 50990-RP01
    Anti-Carboxypeptidase M Antibody Rabbit Polyclonal ELISA 50990-T16
    Anti-Carboxypeptidase M Antibody Rabbit Polyclonal ELISA,IHC-P 11228-T24
    Anti-Carboxypeptidase M Antibody Rabbit Polyclonal ELISA 11228-RP02
    Anti-Carboxypeptidase M Antibody Rabbit Monoclonal WB,ELISA,IP 11228-R105
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