Anti-Carboxypeptidase B2 Antibody

Cat: 50963-T16
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Anti-Carboxypeptidase B2 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-Carboxypeptidase B2 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Mouse
Specificity
Mouse Carboxypeptidase B2
Immunogen
Recombinant Mouse Carboxypeptidase B2 / CPB2 protein (Catalog#50963-M08H)
Preparation
Produced in rabbits immunized with purified, recombinant Mouse Carboxypeptidase B2 / CPB2 (Catalog#50963-M08H; Q9JHH6; Met1-Thr422). Carboxypeptidase B2 / CPB2 specific IgG was purified by Mouse Carboxypeptidase B2 / CPB2 affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-Carboxypeptidase B2 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-Carboxypeptidase B2 Antibody Alternative Names
Anti-1110032P04Rik Antibody;Anti-4930405E17Rik Antibody;Anti-AI255929 Antibody;Anti-CPR Antibody;Anti-Cpu Antibody;Anti-TAFI Antibody
Carboxypeptidase B2 Background Information

Carboxypeptidase B2, also known as Carboxypeptidase U, Thrombin-activable fibrinolysis inhibitor, Plasma carboxypeptidase B, CPB2, is a secreted protein which belongs to the peptidase M14 family. Carboxypeptidases are enzymes that hydrolyze C-terminal peptide bonds. The carboxypeptidase family includes metallo-, serine, and cysteine carboxypeptidases. According to their substrate specificity, these enzymes are referred to as carboxypeptidase A (cleaving aliphatic residues) or carboxypeptidase B (cleaving basic amino residues). CPB2 is activated by thrombin and acts on carboxypeptidase B substrates. After thrombin activation, the mature protein downregulates fibrinolysis. CPB2 is synthesized by the liver and circulates in the plasma as a plasminogen-bound zymogen. When it is activated by proteolysis at residue Arg92 by the thrombin / thrombomodulin complex. CPB2 cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. CPB2 exhibits carboxypeptidase activity and activated CPB2 reduces fibrinolysis by removing the fibrin C-terminal residues that are important for the binding and activation of plasminogen.

Full Name
carboxypeptidase B2 (plasma)
References
  • Eaton DL. et al.,1991, J Biol Chem. 266 (32): 21833-8.
  • Boffa MB. et al.,1999, Biochemistry. 38 (20): 6547-58.
  • Liu T. et al., 2005, J. Proteome Res. 4: 2070-80.
  • Valnickova Z. et al., 2006, Biochemistry. 45: 1525-35.
  • Chen R. et al., 2009, J. Proteome Res. 8: 651-61.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-Carboxypeptidase B2 Antibody Rabbit Polyclonal ELISA 50963-RP01
    Anti-Carboxypeptidase B2 Antibody Rabbit Monoclonal ELISA 50963-R173
    Anti-Carboxypeptidase B2 Antibody Rabbit Polyclonal ELISA 11504-RP01
    Anti-Carboxypeptidase B2 Antibody Rabbit Polyclonal IHC-P 11504-RP02
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