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Carboxypeptidase B1 / CPB1 Antibody, Rabbit MAb
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Carboxypeptidase B1 / CPB1 Antibody, Rabbit MAb PDF Download

Catalog   Size (Price) Quantity In Stock Operation
10501-R329  

YES   
 

Primary antibody | Secondary antibody | Tag antibody | Isotype control antibody | Loading control antibody | Antibody Purification

Carboxypeptidase B1 / CPB1 Antibody Datasheet

  Order or Inquire for Carboxypeptidase B1 / CPB1 Antibody product Quality antibodies Antibody production services
  Detection limit is 0.039 ng/well in ELISA
 

Carboxypeptidase B1 / CPB1 Antibody Product Information

Immunogen :

Recombinant Human Carboxypeptidase B1 / CPB1 protein (Catalog#10501-H08H)

Antibody Type : Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )

Clone ID :

329

Ig Type :

Rabbit IgG

Formulation : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
Preparation :

This antibody was obtained from a rabbit immunized with purified, recombinant Human Carboxypeptidase B1 / CPB1 (rh Carboxypeptidase B1 / CPB1; Catalog#10501-H08H; NP_001862.2; Met 1-Tyr 417).

Carboxypeptidase B1 / CPB1 Antibody Usage Guide

Specificity :

Human Carboxypeptidase B1 / CPB1

 

No cross-reactivity in ELISA with

Mouse CPB1

Human CPA1

Human CPA2

Human CPE

Direct ELISA : This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human CPB1. The detection limit for Human CPB1 is approximately 0.039 ng/well.
Storage : This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Carboxypeptidase B1 / CPB1 Antibody Related Products & Topics

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Proteins:

Antibodies:

Carboxypeptidase B1 / CPB1 Antibody Background

Carboxypeptidase B1, also well known as pancreatic procarboxypeptidase B (PCPB), is a highly pancreas -specific protein (PASP), and has been identified previously as a serum marker for acute pancreatitis and pancreatic graft rejection. As the prototype for those human exopeptidases that cleave off basic C-terminal residues, CPB1 specifically cleaves the C-terminal Arg and Lys residues with a preference for Arg. The B1 and B2 forms of procarboxypeptidase B differ from each other mainly in isoelectric point.The deduced amino acid sequence of PCPB predicts a 416-amino acid preproenzyme consisting of a 15-aa signal peptide, a 95-aa activation peptide and a 307-aa mature chain. The secreted PCPB zymogen is converted to enzymatically active CPB1 by limited proteolysis by trypsin.

References

  1. Yamamoto, K.K. et al., 1992, J. Biol. Chem. 267: 2575-2581.
  2. Pezzilli, R. et al., 1994, Digestion. 55: 73-77.
  3. Barbosa Pereira, P.J. et al., 2002, J. Mol. Biol. 321: 537-547.
 
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