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Carboxypeptidase B1 / CPB1 Antibody Datasheet
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|Detection limit is 0.039 ng/well in ELISA|
Carboxypeptidase B1 / CPB1 Antibody Product Information
Recombinant Human Carboxypeptidase B1 / CPB1 protein (Catalog#10501-H08H)
|Antibody Type :||Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )|
Clone ID :
|Ig Type :||
|Formulation :||0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.|
This antibody was obtained from a rabbit immunized with purified, recombinant Human Carboxypeptidase B1 / CPB1 (rh Carboxypeptidase B1 / CPB1; Catalog#10501-H08H; NP_001862.2; Met 1-Tyr 417).
Carboxypeptidase B1 / CPB1 Antibody Usage Guide
Human Carboxypeptidase B1 / CPB1
No cross-reactivity in ELISA with
|Direct ELISA :||This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human CPB1. The detection limit for Human CPB1 is approximately 0.039 ng/well.|
|Storage :||This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Carboxypeptidase B1 / CPB1 Antibody Related Products & Topics
Carboxypeptidase B1 / CPB1 Antibody Background
Carboxypeptidase B1, also well known as pancreatic procarboxypeptidase B (PCPB), is a highly pancreas -specific protein (PASP), and has been identified previously as a serum marker for acute pancreatitis and pancreatic graft rejection. As the prototype for those human exopeptidases that cleave off basic C-terminal residues, CPB1 specifically cleaves the C-terminal Arg and Lys residues with a preference for Arg. The B1 and B2 forms of procarboxypeptidase B differ from each other mainly in isoelectric point.The deduced amino acid sequence of PCPB predicts a 416-amino acid preproenzyme consisting of a 15-aa signal peptide, a 95-aa activation peptide and a 307-aa mature chain. The secreted PCPB zymogen is converted to enzymatically active CPB1 by limited proteolysis by trypsin.
- Yamamoto, K.K. et al., 1992, J. Biol. Chem. 267: 2575-2581.
- Pezzilli, R. et al., 1994, Digestion. 55: 73-77.
- Barbosa Pereira, P.J. et al., 2002, J. Mol. Biol. 321: 537-547.