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Carboxypeptidase A1 / CPA1 Antibody, Rabbit PAb, Antigen Affinity Purified

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Human CPA1 Antibody Product Information
Immunogen:Recombinant Human Carboxypeptidase A1 / CPA1 protein (Catalog#10504-H08H)
Clone ID:
Ig Type:Rabbit IgG
Concentration:
Endotoxin:
Formulation:0.2 μm filtered solution in PBS with 5% trehalose
Preparation:Produced in rabbits immunized with purified, recombinant Human Carboxypeptidase A1 / CPA1 (rh Carboxypeptidase A1 / CPA1; Catalog#10504-H08H; NP_001859.1; Met 1-Tyr 419). Carboxypeptidase A1 / CPA1 specific IgG was purified by Human Carboxypeptidase A1 / CPA1 affinity chromatography.
Human CPA1 Antibody WB Application Image
Human CPA1 Antibody IHC Application Image
Carboxypeptidase A1 / CPA1 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
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Caption:
Immunochemical staining of human CPA1 in human pancreas with rabbit polyclonal antibody (0.2 µg/mL, formalin-fixed paraffin embedded sections).
Human CPA1 Antibody IP Application Image
Other CPA1 Antibody Products
Carboxypeptidase A1/CPA1 Background

Human Carboxypeptidase A1 (CPA1)is secreted as a pancreatic procarboxypeptidase, and cleaves the C-terminal amide or ester bond of peptides that have a free C-terminal carboxyl group, with the preference of  residues with aromatic or branched aliphatic side chains. CPA1 comprises a signal peptide, a pro region and a mature chain, and can be activated after cleavage of the pro peptide. In contrast to procarboxypeptidase B which was always secreted by the pancreas as a monomer, procarboxypeptidase A occurs as a monomer and/or associated to one or two functionally different proteins, such as zymogen E, and is involved in zymogen inhibition. Three different forms of human pancreatic procarboxypeptidase A have been isolated.

Human Carboxypeptidase A1/CPA1 References
  • Catasus, L. et al., 1992, Biochem. J. 287: 299-303.
  • Moulard, M. et al., 1990, FEBS. Lett. 261: 179-183.
  • Aloy, P. et al., 1998, Biol. Chem. 379: 149-155.
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