Carbonic Anhydrase XIII/CA13

The carbonic anhydrases (or carbonate dehydratases) are classified as metalloenzyme for its zinc ion prosthetic group and form a family of enzymes that catalyze the rapid interconversion of carbon dioxide and water to bicarbonate and protons, a reversible reaction that takes part in maintaining acid-base balance in blood and other tissues. The carbonic anhydrasekl (CA) family consists of at least 11 enzymatically active members and a few inactive homologous proteins. The CAXIII is a member of the CA family, which owns a globular molecule with high structural similarity to cytosolic isozymes, CAI, II, and III. Recombinant mouse CAXIII showed catalytic activity similar to those of mitochondrial CAV and cytosolic CAI. In human tissues, CAXIII expression was identified in the thymus, small intestine, spleen, prostate, ovary, colon, and testis. In mouse, positive tissues included the spleen, lung, kidney, heart, brain, skeletal muscle, and testis. In conclusion, the predicted amino acid sequence, structural model, distribution, and activity data suggest that CAXIII represents a novel enzyme, which may play important physiological roles in several organs.

Carbonic Anhydrase XIII/CA13 Related Areas

Enzyme>>Carbonic Anhydrase>>Carbonic Anhydrase XIII

Carbonic Anhydrase XIII/CA13 Alternative Names

Carbonic Anhydrase XIII, CA13, CA-XIII, CAXIII, FLJ37995, MGC59868 [Homo sapiens]

Carbonic Anhydrase XIII, Car13, CA-XIII, 2310075C21Rik, Ca13 [Mus musculus]

Summaries for Carbonic Anhydrase XIII/CA13

Entrez Gene summary for Carbonic Anhydrase XIII/CA13:

Carbonic anhydrases (CAs) are a family of zinc metalloenzymes. For background information on the CA family, see MIM 114800

OMIM - description for Carbonic Anhydrase XIII/CA13:

Carbonic anhydrases (CAs) are a family of zinc metalloenzymes. For background information on the CA family, see 114800. By sequence comparison of a mouse Ca13 cDNA to others in databases, Lehtonen et al. (2004) identified the human CA13 cDNA sequence, encoding 262 amino acids. Western blot analysis showed a single 30-kD CA13 peptide in human and mouse colon. Immunolocalization studies revealed that CA13 was a cytosolic protein. Immunohistochemical analysis showed widespread expression of CA13 in human and mouse tissues, although its distribution differed between human and mouse. While CA13 was expressed at all stages of sperm development in human testis, it was not observed in mouse spermatozoa.

Wikipedia summary for Carbonic Anhydrase XIII/CA13:

Human Carbonic Anhydrase XIII/CA13 Protein General Information

 

• Protein names: Recommended name: Carbonic anhydrase 13 EC=4.2.1.1
• Sequence length: 262 AA.
• Sequence similarities: Belongs to the alpha-carbonic anhydrase family.
• Enzyme regulation: Inhibited by acetazolamide.
• Cofactor: Zinc
• Tissue specificity: Expressed in thymus, small intestine, spleen, prostate, ovary, colon and testis.

General information above from UniProt

Function for Carbonic Anhydrase XIII/CA13 Protein

UniProtKB:

Reversible hydration of carbon dioxide.

Genatlas:

• Carbonic Anhydrase XIII/CA13 is involved in reversible hydration of carbon dioxide
• carbonic anhydrase gene family