Carbonic Anhydrase VII

Reversible hydration of carbon dioxide.

Carbonic Anhydrase VII Related Areas

Enzyme>>Carbonic Anhydrase>>Carbonic Anhydrase VII

Carbonic Anhydrase VII Alternative Names

Carbonic Anhydrase VII, CA VII, CA7, CAVII [Homo sapiens]

Carbonic Anhydrase VII, CA VII, Ca7, Car7, AV343731 [Mus musculus]

Summaries for Carbonic Anhydrase VII

Entrez Gene summary for Carbonic Anhydrase VII:

Carbonic anhydrases are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. The cytosolic protein encoded by this gene is predominantly expressed in the salivary glands. Alternative splicing in the coding region results in multiple transcript variants encoding different isoforms.

OMIM - description for Carbonic Anhydrase VII:

Carbonic anhydrases (CAs) are a family of zinc metalloenzymes. For background information on the CA family, see 114800. Venta et al. (1987) described the partial characterization of carbonic anhydrase VII. Montgomery et al. (1987, 1991) mapped the partially characterized CA7 isozyme to chromosome 16q21-q23 by analysis of somatic cell hybrids and by in situ hybridization. The mRNA for CA VII was detected only in salivary glands.

Wikipedia summary for Carbonic Anhydrase VII:

Carbonic anhydrase 7 is an enzyme that in humans is encoded by the CA7 gene.Carbonic anhydrases are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. The cytosolic protein encoded by this gene is predominantly expressed in the salivary glands. Alternative splicing in the coding region results in multiple transcript variants encoding different isoforms

Human Carbonic Anhydrase VII Protein General Information

 

• Protein names: Recommended name: Carbonic anhydrase 7
• Sequence length: 264 AA.
• Catalytic activity: H2CO3 = CO2 + H2O.
• Sequence similarities: Belongs to the alpha-carbonic anhydrase family.
• Enzyme regulation: Activated by histamine, L-adrenaline, L- and D-histidine, and L- and D-phenylalanine. Inhibited coumarins, sulfonamide derivatives such as acetazolamide (AZA), by saccharin and Foscarnet (phosphonoformate trisodium salt).
• Cofactor: Zinc.
• Subcellular location: Cytoplasm

General information above from UniProt

Function for Carbonic Anhydrase VII Protein

UniProtKB:

Reversible hydration of carbon dioxide.

Genatlas:

• alpha-carbonic anhydrase family
• carbonic anhydrase VII, reversibly hydrating Co2 in cellular ion transport and pH homeostasis