Carbonic Anhydrase VA

Reversible hydration of carbon dioxide. Low activity.

Carbonic Anhydrase VA Related Areas

Enzyme>>Carbonic Anhydrase>>Carbonic Anhydrase VA

Carbonic Anhydrase VA Alternative Names

Carbonic Anhydrase VA, CA5A, CA-VA, CA5, CAV, CAVA [Homo sapiens]

Carbonic Anhydrase VA, Car5a, CAV, Ca5a, Car5, CA Y, CA-VA [Mus musculus]

Summaries for Carbonic Anhydrase VA

Entrez Gene summary for Carbonic Anhydrase VA:

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA VA is localized in the mitochondria and expressed primarily in the liver. It may play an important role in ureagenesis and gluconeogenesis. CA5A gene maps to chromosome 16q24.3 and an unprocessed pseudogene has been assigned to 16p12-p11.2

OMIM - description for Carbonic Anhydrase VA:

Carbonic anhydrases (CAs) are a family of zinc metalloenzymes. For background information on the CA family, see 114800. Using a mouse cDNA that presumably encoded a mitochondrial carbonic anhydrase, Nagao et al. (1993) isolated a full-length cDNA clone encoding human CA V from a human liver cDNA library. The N-terminal sequence was determined directly on the 30-kD soluble CA V purified from COS cells transfected with the cDNA. These sequence data indicated that processing of the precursor polypeptide to mature human CA V involves removal of a 38-amino acid mitochondrial leader sequence. Nagao et al. (1993) found that the 267-amino acid sequence deduced for mature human CA V is 30 to 49% homologous to amino acid sequences of previously characterized human CAs and 76% homologous to the amino acid sequence deduced from the mouse cDNA for CA5.

Wikipedia summary for Carbonic Anhydrase VA:

Human Carbonic Anhydrase VA Protein General Information

 

• Protein names: Recommended name: Carbonic anhydrase 5A, mitochondrial
• Sequence length: 305 AA.
• Catalytic activity: H2CO3 = CO2 + H2O.
• Sequence similarities: Belongs to the alpha-carbonic anhydrase family.
• Enzyme regulation: Activated by histamine, L-adrenaline, L- and D-histidine, and L- and D-phenylalanine. Inhibited by coumarins, sulfonamide derivatives such as acetazolamide and Foscarnet (phosphonoformate trisodium salt)
• Subcellular location: Mitochondrion.

General information above from UniProt

Function for Carbonic Anhydrase VA Protein

UniProtKB:

Reversible hydration of carbon dioxide. Low activity.

Genatlas:

• Carbonic Anhydrase VA is putatively involved in ureagenesis, gluconeogenesis
• Carbonic Anhydrase VA reversibly hydrate CO2 in cellular ion transport and pH homeostasis