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Carbonic Anhydrase

Sino Biological offers quality products directed towards carbonic anhydrases, including recombinant proteins, antibodies (rabbit MAbs, mouse MAbs, rabbit PAbs), ELISA kits, and gene cDNA clones.

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    Carbonic Anhydrase Background

    The carbonic anhydrases (or carbonate dehydratases) are a family of enzymes that catalyze the rapid conversion of carbonic acid to bicarbonate and protons. Carbonic anhydrases are classified as metalloenzymes, because the active site of most carbonic anhydrases contains a zinc ion. There are at least five distinct carbonic anhydrase families (α, β, γ, δ and ε), of which the alpha- carbonic anhydrases are found in mammals, while the other carbonic anhydrase families are found in plants or micro organisms. Carbonic anhydrases catalyze the reversible reaction of CO2 + H2O = HCO3- + H+, which is to interconvert carbon dioxide and bicarbonate to maintain acid-base balance in blood and other tissues, and to help transport carbon dioxide out of tissues. Carbonic anhydrase inhibitors have been used theraputically. Their clinical use has been established as antiglaucoma agents, antiepileptics, in the management of neurological disorders, mountain sickness, gastric ulcers, or osteoporosis.

    Carbonic Anhydrase References

      1. Breton S. (2001) The cellular physiology of carbonic anhydrases. JOP. 2(4 Suppl):159-64.
      2. Winum JY, et al. (2009) Therapeutic applications of glycosidic carbonic anhydrase inhibitors. Med Res Rev. 29(3):419-35.
      3. Winum JY, et al. (2009) Inhibition of carbonic anhydrase IX: a new strategy against cancer. Anticancer Agents Med Chem. 9(6):693-702.
      4. Poulsen SA. (2010) Carbonic anhydrase inhibition as a cancer therapy: a review of patent literature, 2007 - 2009. Expert Opin Ther Pat. 20(6):795-806.
      5. Supuran CT. (2010) Carbonic anhydrase inhibitors. Bioorg Med Chem Lett. 20(12):3467-74.