Anti-Carbonic Anhydrase XIV Antibody

Cat: 10458-RP02
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Anti-Carbonic Anhydrase XIV Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-Carbonic Anhydrase XIV Antibody
Validated applications
ELISA,IHC-P
Species reactivity
Reacts with: Human, Mouse, Rat
Specificity
Human Carbonic Anhydrase XIV
Immunogen
Recombinant Human CA14 protein (Catalog#10458-H08H)
Preparation
Produced in rabbits immunized with purified, recombinant Human CA14 / Car14 extracellular domain (rh CA14; Catalog#10458-H08H; NP_036245.1; Met 1-Met 290). CA14 specific IgG was purified by human CA14 affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-Carbonic Anhydrase XIV Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 0.5-1.0 μg/mL  
IHC-P 0.2-2 μg/mL  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-Carbonic Anhydrase XIV Antibody (Rabbit Polyclonal antibody) Images
Human Carbonic Anhydrase XIV Immunohistochemistry(IHC) 2733
Immunohistochemical staining of formalin fixed, paraffin-embedded human brain showing neuron staining (0.5 μg/mL).
Human Carbonic Anhydrase XIV Immunohistochemistry(IHC) 4631
Immunochemical staining of human CA14 in human liver with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections). Positive staining was localized to membrane of hepatocyte. The left panel: tissue incubated with primary antibody; The right panel: tissue incubated with the mixture of primary antibody and antigen (recombinant protein).
Anti-Carbonic Anhydrase XIV Antibody Alternative Names
Anti-CA14 Antibody;Anti-CAXiV Antibody
Carbonic Anhydrase XIV Background Information

The carbonic anhydrases (or carbonate dehydratases) are classified as metalloenzyme for its zinc ion prosthetic group and form a family of enzymes that catalyze the rapid interconversion of carbon dioxide and water to bicarbonate and protons, a reversible reaction that takes part in maintaining acid-base balance in blood and other tissues. The carbonic anhydrasekl (CA) family consists of at least 11 enzymatically active members and a few inactive homologous proteins. CAXIV is a member of CA family that showed an overall similarity of 29–46% to other active CA isozymes. The highest percentage similarity was with a transmembrane CA isoform, CAXII. The CAXIV was found high concentrations in human heart, brain, liver, and skeletal muscle but lower in the colon, small intestine, urinary bladder, and kidney. No CAXIV mRNA was seen in the salivary gland and pancreas. CAXIV is a likely candidate for the extracellular CA postulated to have an important role in modulating excitatory synaptic transmission in brain.

Full Name
carbonic anhydrase XIV
References
  • Lehtonen J, et al. (2004) Characterization of CA XIII, a Novel Member of the Carbonic Anhydrase Isozyme Family. The Journal of Biological Chemistry. 279: 2719-27.
  • Lindskog S. (1997) Structure and mechanism of carbonic anhydrase. Pharmacology & Therapeutics. 74(1):1-20.
  • Parkkila S, et al. (2001) Expression of membrane-associated carbonic anhydrase XIV on neurons and axons in mouse and human brain. PNAS. 98(4): 1918-23.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-Carbonic Anhydrase XIV Antibody Rabbit Polyclonal WB,ELISA 50013-RP01
    Anti-Carbonic Anhydrase XIV Antibody Rabbit Polyclonal WB,ELISA 50013-RP02
    Anti-Carbonic Anhydrase XIV Antibody Rabbit Monoclonal ELISA 50013-R033
    Anti-Carbonic Anhydrase XIV Antibody Rabbit Monoclonal ELISA,IHC-P,ICC/IF,IF 10458-R515
    Anti-Carbonic Anhydrase XIV Antibody Rabbit Monoclonal ELISA(Cap) 10458-R110
    Anti-Carbonic Anhydrase XIV Antibody Rabbit Polyclonal WB,ELISA,IHC-P,IP 10458-T60
    Anti-Carbonic Anhydrase XIV Antibody Rabbit Monoclonal WB,ELISA 10458-R004
    Anti-Carbonic Anhydrase XIV Antibody Rabbit Polyclonal ELISA 10458-RP01
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