Anti-CA12 Antibody (PE)

Cat: 10617-MM11-P
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Anti-CA12 Antibody (PE) (Mouse Monoclonal antibody) General Information
Product name
Anti-CA12 Antibody (PE)
Validated applications
FCM
Species reactivity
Reacts with: Human
Specificity
Human CA12
Immunogen
Recombinant Human Carbonic Anhydrase XII / CA12 protein (Catalog#10617-H08H)
Preparation
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Carbonic Anhydrase XII / CA12 (rh Carbonic Anhydrase XII / CA12; Catalog#10617-H08H; NP_001209.1; Met1-Gln291) and conjugated with PE under optimum conditions, the unreacted PE was removed.
Source
Monoclonal Mouse IgG1 Clone #11
Purification
Protein A
Formulation
Aqueous solution containing 0.5% BSA and 0.09% sodium azide
Conjugate
PE
Concentration
2 μl/Test, 0.1 mg/ml
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
Anti-CA12 Antibody (PE) (Mouse Monoclonal antibody) Validated Applications

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-CA12 Antibody (PE) (Mouse Monoclonal antibody) Images
Human Carbonic Anhydrase XII Flow Cytometry (FC) 5423
Flow cytometric analysis of anti-Human CA12 on MCF-7 cells. The 10617-MM11 and 10617-MM07 monoclonal antibodies cross-block binding, suggesting recongnition of overlapping epitopes.
Anti-CA12 Antibody (PE) Alternative Names
Anti-CA12 Antibody;Anti-CAXII Antibody;Anti-FLJ20151 Antibody;Anti-HsT18816 Antibody
CA12 Background Information

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes first discovered in 1933 that catalyze the reversible hydration of carbon dioxide. CAs participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. CA12, also known as Car12 and carbonic anhydrase XII, is a type I  membrane enzyme of an N-terminal extracellular catalytic domain, a membrane-spanning α-helix, and a small intracellular C-terminal domain. It is highly expressed in colon, kidney, prostate, intestine and activated lymphocytes and moderately expressed in pancreas, ovary, and testis. Overexpression of the CA12 is observed in certain human cancers and is used as a tumor marker. rmCA12 corresponds to the extracellular domain and has both carbonic anhydrase activity and esterase activity.

Full Name
carbonic anhydrase XII
References
  • Sahin, U. et al., 1996, Proc. Natl. Acad. Sci. U.S.A. 92 (25): 11810–11813.
  • Ivanov, S.V. et al., 1998, Proc. Natl. Acad. Sci. USA 95:12596 - 12601.
  • Strausberg, R.L. et al., 2002, Proc. Natl. Acad. Sci. USA 99:16899 - 16903.
  • Liao, S.Y. et al., 2003, J. Med. Genet. 40:257 - 262.
  • Supuran, C. T. et al., 2008, Curr Pharm Des. 14 (7): 601-602.
  • Elleuche, S. et al., 2009, Curr Genet. 55 (2): 211-222.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-CA12 Antibody Rabbit Monoclonal ELISA,IHC-P 50014-R012
    Anti-CA12 Antibody Rabbit Polyclonal ELISA 50014-RP01
    Anti-CA12 Antibody Rabbit Polyclonal ELISA,IHC-P 50014-RP02
    Anti-CA12 Antibody Rabbit Monoclonal ELISA 50014-R003
    Anti-CA12 Antibody Rabbit Monoclonal ELISA 50014-R001
    Anti-CA12 Antibody (PE) Mouse Monoclonal FCM 10617-MM07-P
    Anti-CA12 Antibody Rabbit Polyclonal WB,IHC-P 10617-RP02
    Anti-CA12 Antibody Mouse Monoclonal ICC/IF,IF 10617-MM04
    Anti-CA12 Antibody Mouse Monoclonal ELISA,ELISA(Det) 10617-MM08
    Anti-CA12 Antibody Mouse Monoclonal FCM,ICC/IF,IF 10617-MM07
    Anti-CA12 Antibody Mouse Monoclonal FCM 10617-MM11
    Anti-CA12 Antibody Mouse Monoclonal ELISA(Cap) 10617-MM01
    Anti-CA12 Antibody (FITC) Mouse Monoclonal FCM 10617-MM07-F
    Anti-CA12 Antibody (FITC) Mouse Monoclonal FCM 10617-MM11-F
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