Anti-CA12 Antibody

Cat: 50014-R012
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Anti-CA12 Antibody (Rabbit Monoclonal antibody) General Information
Product name
Anti-CA12 Antibody
Validated applications
ELISA,IHC-P
Species reactivity
Reacts with: Mouse
Specificity
Mouse CA12
Immunogen
Recombinant Mouse Carbonic Anhydrase XII / CA12 Protein (Catalog#50014-M08H)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse Carbonic Anhydrase XII / CA12 (rM Carbonic Anhydrase XII / CA12; Catalog#50014-M08H; NP_848483.2; Met 1-Ser 301).
Source
Monoclonal Rabbit IgG Clone #012
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-CA12 Antibody (Rabbit Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  
IHC-P 1:100-1:500  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-CA12 Antibody (Rabbit Monoclonal antibody) Images
Mouse Carbonic Anhydrase XII Immunohistochemistry(IHC) 3377
Immunochemical staining of mouse CA12 in mouse kidney with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections).
Mouse Carbonic Anhydrase XII Immunohistochemistry(IHC) 3378
Immunochemical staining of mouse CA12 in mouse intestine with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections).
Anti-CA12 Antibody Alternative Names
Anti-2310047E01Rik Antibody;Anti-AI314958 Antibody;Anti-Car12 Antibody
CA12 Background Information

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes first discovered in 1933 that catalyze the reversible hydration of carbon dioxide. CAs participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. CA12, also known as Car12 and carbonic anhydrase XII, is a type I  membrane enzyme of an N-terminal extracellular catalytic domain, a membrane-spanning α-helix, and a small intracellular C-terminal domain. It is highly expressed in colon, kidney, prostate, intestine and activated lymphocytes and moderately expressed in pancreas, ovary, and testis. Overexpression of the CA12 is observed in certain human cancers and is used as a tumor marker. rmCA12 corresponds to the extracellular domain and has both carbonic anhydrase activity and esterase activity.

Full Name
carbonic anhydrase XII
References
  • Sahin, U. et al., 1996, Proc. Natl. Acad. Sci. U.S.A. 92 (25): 11810–11813.
  • Ivanov, S.V. et al., 1998, Proc. Natl. Acad. Sci. USA 95:12596 - 12601.
  • Strausberg, R.L. et al., 2002, Proc. Natl. Acad. Sci. USA 99:16899 - 16903.
  • Liao, S.Y. et al., 2003, J. Med. Genet. 40:257 - 262.
  • Supuran, C. T. et al., 2008, Curr Pharm Des. 14 (7): 601-602.
  • Elleuche, S. et al., 2009, Curr Genet. 55 (2): 211-222.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-CA12 Antibody Rabbit Polyclonal ELISA 50014-RP01
    Anti-CA12 Antibody Rabbit Polyclonal ELISA,IHC-P 50014-RP02
    Anti-CA12 Antibody Rabbit Monoclonal ELISA 50014-R003
    Anti-CA12 Antibody Rabbit Monoclonal ELISA 50014-R001
    Anti-CA12 Antibody (PE) Mouse Monoclonal FCM 10617-MM07-P
    Anti-CA12 Antibody (PE) Mouse Monoclonal FCM 10617-MM11-P
    Anti-CA12 Antibody Mouse Monoclonal ICC/IF,IF 10617-MM04
    Anti-CA12 Antibody Mouse Monoclonal ELISA,ELISA(Det) 10617-MM08
    Anti-CA12 Antibody Rabbit Polyclonal WB,IHC-P 10617-RP02
    Anti-CA12 Antibody Mouse Monoclonal FCM,ICC/IF,IF 10617-MM07
    Anti-CA12 Antibody Mouse Monoclonal FCM 10617-MM11
    Anti-CA12 Antibody Mouse Monoclonal ELISA(Cap) 10617-MM01
    Anti-CA12 Antibody (FITC) Mouse Monoclonal FCM 10617-MM07-F
    Anti-CA12 Antibody (FITC) Mouse Monoclonal FCM 10617-MM11-F
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