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Carbonic Anhydrase XII / Car12 Antibody, Rabbit MAb

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Mouse CA12 Antibody Product Information
Immunogen:Recombinant Mouse Carbonic Anhydrase XII / CA12 Protein (Catalog#50014-M08H)
Clone ID:012
Ig Type:Rabbit IgG
Concentration:
Endotoxin:
Formulation:0.2 μm filtered solution in PBS with 5% trehalose
Preparation:This antibody was obtained from a rabbit immunized with purified, recombinant Mouse Carbonic Anhydrase XII / CA12 (rM Carbonic Anhydrase XII / CA12; Catalog#50014-M08H; NP_848483.2; Met 1-Ser 301).
Mouse CA12 Antibody Usage Guide
Specificity:Mouse Carbonic Anhydrase XII / CA12
Application:ELISA, IHC-P

ELISA: 0.1-0.2 μg/mL

This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Mouse CA12. The detection limit for Mouse CA12 is approximately 0.00245 ng/well.

IHC-P: 1-10 μg/mL

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Mouse CA12 Antibody IHC Application Image
Carbonic Anhydrase XII / Car12 Antibody, Rabbit MAb, Immunohistochemistry
[Click to enlarge image]
Caption:
Immunochemical staining of mouse CA12 in mouse intestine with rabbit monoclonal antibody (5 µg/mL, formalin-fixed paraffin embedded sections).
Carbonic Anhydrase XII / Car12 Antibody, Rabbit MAb, Immunohistochemistry
[Click to enlarge image]
Caption:
Immunochemical staining of mouse CA12 in mouse kidney with rabbit monoclonal antibody (5 µg/mL, formalin-fixed paraffin embedded sections).
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          Carbonic Anhydrase XII Background

          Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes first discovered in 1933 that catalyze the reversible hydration of carbon dioxide. CAs participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. CA12, also known as Car12 and carbonic anhydrase XII, is a type I  membrane enzyme of an N-terminal extracellular catalytic domain, a membrane-spanning α-helix, and a small intracellular C-terminal domain. It is highly expressed in colon, kidney, prostate, intestine and activated lymphocytes and moderately expressed in pancreas, ovary, and testis. Overexpression of the CA12 is observed in certain human cancers and is used as a tumor marker. rmCA12 corresponds to the extracellular domain and has both carbonic anhydrase activity and esterase activity.

          Mouse Carbonic Anhydrase XII References
        • Sahin, U. et al., 1996, Proc. Natl. Acad. Sci. U.S.A. 92 (25): 11810–11813.
        • Ivanov, S.V. et al., 1998, Proc. Natl. Acad. Sci. USA 95:12596 - 12601.
        • Strausberg, R.L. et al., 2002, Proc. Natl. Acad. Sci. USA 99:16899 - 16903.
        • Liao, S.Y. et al., 2003, J. Med. Genet. 40:257 - 262.
        • Supuran, C. T. et al., 2008, Curr Pharm Des. 14 (7): 601-602.
        • Elleuche, S. et al., 2009, Curr Genet. 55 (2): 211-222.
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          Size / Price
          Catalog: 50014-R012-50
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          All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
          Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"