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Carbonic Anhydrase VII Protein, Antibody, ELISA Kit, cDNA Clone

Carbonic Anhydrase VII Related Areas

Carbonic Anhydrase VII Related Pathways

Carbonic Anhydrase VII Related Product

    Carbonic Anhydrase VII Summary & Protein Information

    Carbonic Anhydrase VII Background

    Gene Summary: Carbonic anhydrases are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. The cytosolic protein encoded by this gene is predominantly expressed in the salivary glands. Alternative splicing in the coding region results in multiple transcript variants encoding different isoforms.
    General information above from NCBI
    Catalytic activity: H(2)CO(3) = CO(2) + H(2)O.
    Cofactor: Zinc.
    Enzyme regulation: Activated by histamine, L-adrenaline, L- and D- histidine, and L- and D-phenylalanine. Inhibited coumarins, sulfonamide derivatives such as acetazolamide (AZA), by saccharin and Foscarnet (phosphonoformate trisodium salt).
    Subcellular location: Cytoplasm (Probable).
    Sequence similarity: Belongs to the alpha-carbonic anhydrase family.C
    General information above from UniProt

    Carbonic anhydrase 7, also known as carbonate dehydratase VII, carbonic anhydrase VII, CA-VII and CA7, is a cytoplasm protein which belongs to the alpha-carbonic anhydrase family. Carbonic anhydrases are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. Carbonic anhydrases show extensive diversity in tissue distribution and in their subcellular localization. CA7 / CA-VII is predominantly expressed in the salivary glands. Alternative splicing in the coding region results in multiple transcript variants encoding different isoforms.

    Carbonic Anhydrase VII Alternative Name

    CA VII,CA7,CAVII,Carbonic Anhydrase VII, [human]
    AV343731,CA VII,Ca7,Car7,Carbonic Anhydrase VII, [mouse]

    Carbonic Anhydrase VII Related Studies

  • Montgomery J.C., et al., 1991, Genomics 11:835-848.
  • Temperini C., et al., 2006, Chemistry 12:7057-7066.
  • Temperini C., et al., 2007, Bioorg. Med. Chem. Lett. 17:628-635.
  • Maresca A., et al., 2009, J. Am. Chem. Soc. 131:3057-3062.
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