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Carbonic Anhydrase IX/CA9 Protein, Antibody, ELISA Kit, cDNA Clone

Mouse Carbonic Anhydrase IX/CA9 Protein

Description: Active
Expression host: Human Cells
  • Slide 1
50660-M08H-10
50660-M08H-20
10 µg / $140
20 µg / $230
Add to Cart

Canine Carbonic Anhydrase IX/CA9 Protein

Description: Active
Expression host: Human Cells
  • Slide 1
70028-D02H-10
70028-D02H-20
10 µg / $140
20 µg / $250
Add to Cart
Description: Active
Expression host: Human Cells
  • Slide 1
70028-D08H-10
70028-D08H-20
10 µg / $140
20 µg / $250
Add to Cart

Human Carbonic Anhydrase IX/CA9 Protein

Description: Active
Expression host: Human Cells
  • Slide 1
10107-H02H-10
10107-H02H-20
10 µg / $140
20 µg / $250
Add to Cart
Description: Active
Expression host: Human Cells
  • Slide 1
10107-H08H-10
10107-H08H-20
10 µg / $140
20 µg / $240
Add to Cart

Carbonic Anhydrase IX/CA9 Related Areas

Carbonic Anhydrase IX/CA9 Related Pathways

Carbonic Anhydrase IX/CA9 Related Product

    Carbonic Anhydrase IX/CA9 Background

    Gene Summary: Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA IX is a transmembrane protein and the only tumor-associated carbonic anhydrase isoenzyme known. It is expressed in all clear-cell renal cell carcinoma, but is not detected in normal kidney or most other normal tissues. It may be involved in cell proliferation and transformation. This gene was mapped to 17q21.2 by fluorescence in situ hybridization, however, radiation hybrid mapping localized it to 9p13-p12.
    General information above from NCBI
    Catalytic activity: H(2)CO(3) = CO(2) + H(2)O.
    Cofactor: Zinc.
    Enzyme regulation: Inhibited by coumarins, saccharin, sulfonamide derivatives such as acetazolamide (AZA) and Foscarnet (phosphonoformate trisodium salt).
    Subunit structure: Forms oligomers linked by disulfide bonds.
    Subcellular location: Nucleus. Nucleus, nucleolus. Cell membrane; Single-pass type I membrane protein. Cell projection, microvillus membrane; Single-pass type I membrane protein. Note=Found on the surface microvilli and in the nucleus, particularly in nucleolus.
    Tissue specificity: Expressed primarily in carcinoma cells lines. Expression is restricted to very few normal tissues and the most abundant expression is found in the epithelial cells of gastric mucosa.
    Induction: By hypoxia.
    Post-translational: Asn-346 bears high-mannose type glycan structures.
    Sequence similarities: Belongs to the alpha-carbonic anhydrase family.C
    General information above from UniProt

    Carbonic anhydrases IX (CA IX), also known as membrane antigen MN or CA9, is a member of the carbonic anhydrase (CA) family and may be involved in cell proliferation and cellular transformation. CAs are zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide (H2O + CO2 = H+ + HCO3–) and thus participate in a variety of biological and physical processes. CA IX protein is expressed primarily in carcinoma cells lines, and the expression is cell density dependent and has been shown to be strongly induced by hypoxia, accordingly facilitates adaptation of tumor cells to hypoxic conditions. It is involved in tumorigenesis through many pathways, such as pH regulation and cell adhesion control. CA IX is used as a marker of tumor hypoxia and as a new therapeutic target for many human carcinomas and cancers.

    Carbonic Anhydrase IX/CA9 Altermative Names

    Carbonic Anhydrase IX/CA9 Related Studies

  • Loncaster JA, et al. (2001) Carbonic anhydrase (CA IX) expression, a potential new intrinsic marker of hypoxia: correlations with tumor oxygen measurements and prognosis in locally advanced carcinoma of the cervix. Cancer Res. 61(17): 6394-9.
  • Zvada J, et al. (2003) Soluble form of carbonic anhydrase IX (CA IX) in the serum and urine of renal carcinoma patients. Br J Cancer. 89(6): 1067-71.
  • Pan P, et al. (2006) Carbonic anhydrase gene expression in CA II-deficient (Car2-/-) and CA IX-deficient (Car9-/-) mice. J Physiol. 571(Pt 2): 319-27.
  • Zhou GX, et al. (2010) Quantification of carbonic anhydrase IX expression in serum and tissue of renal cell carcinoma patients using enzyme-linked immunosorbent assay: prognostic and diagnostic potentials. Urology. 75(2): 257-61.
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