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Carbonic Anhydrase IX / Car9 Antibody, Rabbit PAb, Antigen Affinity Purified

  • Carbonic Anhydrase IX / Car9 Antibody, Rabbit PAb, Antigen Affinity Purified, Western blot
  • Carbonic Anhydrase IX / Car9 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
  • Carbonic Anhydrase IX / Car9 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
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Mouse CA9 Antibody Product Information
Immunogen:Recombinant Mouse Carbonic Anhydrase IX / CAR9 protein (Catalog#50660-M08H)
Clone ID:
Ig Type:Rabbit IgG
Concentration:
Endotoxin:
Formulation:0.2 μm filtered solution in PBS with 5% trehalose
Preparation:Produced in rabbits immunized with purified, recombinant Mouse Carbonic Anhydrase IX / CAR9 (rM Carbonic Anhydrase IX / CAR9; Catalog#50660-M08H; NP_647466.2; Met 1-Asp 390). Carbonic Anhydrase IX / CAR9 specific IgG was purified by Mouse Carbonic Anhydrase IX / CAR9 affinity chromatography.
Mouse CA9 Antibody WB Application Image
Mouse CA9 Antibody IHC Application Image
Carbonic Anhydrase IX / Car9 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
[Click to enlarge image]
Caption:
Immunochemical staining of mouse CAR9 in mouse intestine with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections).
Carbonic Anhydrase IX / Car9 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
[Click to enlarge image]
Caption:
Immunochemical staining of mouse CAR9 in mouse stomach with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections).
Other CA9 Antibody Products
Carbonic Anhydrase IX/CA9 Background

Carbonic anhydrases IX (CA IX), also known as membrane antigen MN or CA9, is a member of the carbonic anhydrase (CA) family and may be involved in cell proliferation and cellular transformation. CAs are zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide (H2O + CO2 = H+ + HCO3–) and thus participate in a variety of biological and physical processes. CA IX protein is expressed primarily in carcinoma cells lines, and the expression is cell density dependent and has been shown to be strongly induced by hypoxia, accordingly facilitates adaptation of tumor cells to hypoxic conditions. It is involved in tumorigenesis through many pathways, such as pH regulation and cell adhesion control. CA IX is used as a marker of tumor hypoxia and as a new therapeutic target for many human carcinomas and cancers.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Mouse Carbonic Anhydrase IX/CA9 References
  • Loncaster JA, et al. (2001) Carbonic anhydrase (CA IX) expression, a potential new intrinsic marker of hypoxia: correlations with tumor oxygen measurements and prognosis in locally advanced carcinoma of the cervix. Cancer Res. 61(17): 6394-9.
  • Zvada J, et al. (2003) Soluble form of carbonic anhydrase IX (CA IX) in the serum and urine of renal carcinoma patients. Br J Cancer. 89(6): 1067-71.
  • Pan P, et al. (2006) Carbonic anhydrase gene expression in CA II-deficient (Car2-/-) and CA IX-deficient (Car9-/-) mice. J Physiol. 571(Pt 2): 319-27.
  • Zhou GX, et al. (2010) Quantification of carbonic anhydrase IX expression in serum and tissue of renal cell carcinoma patients using enzyme-linked immunosorbent assay: prognostic and diagnostic potentials. Urology. 75(2): 257-61.
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    Catalog: 50660-RP02-50
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    Datasheet & Documentation

    All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"