Quick Order

Carbonic Anhydrase IX / CA9 Antibody, Rabbit MAb

  • Human Carbonic Anhydrase IX/CA9 Immunohistochemistry(IHC) 17444
  • Carbonic Anhydrase IX / CA9 Antibody, Rabbit MAb, Immunohistochemistry
  • Carbonic Anhydrase IX / CA9 Antibody, Rabbit MAb, Immunohistochemistry
  • Carbonic Anhydrase IX / CA9 Antibody, Rabbit MAb, Immunohistochemistry
DatasheetReviewsRelated ProductsProtocols
Human CA9 Antibody Product Information
Immunogen:Recombinant Human Carbonic Anhydrase IX / CA9 protein (Catalog#10107-H08H)
Clone ID:005
Ig Type:Rabbit IgG
Concentration:
Endotoxin:
Formulation:0.2 μm filtered solution in PBS
Preparation:This antibody was obtained from a rabbit immunized with purified, recombinant Human Carbonic Anhydrase IX / CA9 (rh Carbonic Anhydrase IX / CA9; Catalog#10107-H08H; NP_001207.2; Met 1-Asp 414).
Human CA9 Antibody IHC Application Image
Carbonic Anhydrase IX / CA9 Antibody, Rabbit MAb, Immunohistochemistry
[Click to enlarge image]
Caption:
Immunochemical staining of human CA9 in human gastric cancer with rabbit monoclonal antibody (2 µg/mL, formalin-fixed paraffin embedded sections).
Carbonic Anhydrase IX / CA9 Antibody, Rabbit MAb, Immunohistochemistry
[Click to enlarge image]
Caption:
Immunochemical staining of human CA9 in human stomach with rabbit monoclonal antibody (2 µg/mL, formalin-fixed paraffin embedded sections).
Carbonic Anhydrase IX / CA9 Antibody, Rabbit MAb, Immunohistochemistry
[Click to enlarge image]
Caption:
Immunochemical staining of human CA9 in human bladder carcinoma with rabbit monoclonal antibody (5µg/mL, formalin-fixed paraffin embedded sections).
Other CA9 Antibody Products
Carbonic Anhydrase IX/CA9 Background

Carbonic anhydrases IX (CA IX), also known as membrane antigen MN or CA9, is a member of the carbonic anhydrase (CA) family and may be involved in cell proliferation and cellular transformation. CAs are zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide (H2O + CO2 = H+ + HCO3–) and thus participate in a variety of biological and physical processes. CA IX protein is expressed primarily in carcinoma cells lines, and the expression is cell density dependent and has been shown to be strongly induced by hypoxia, accordingly facilitates adaptation of tumor cells to hypoxic conditions. It is involved in tumorigenesis through many pathways, such as pH regulation and cell adhesion control. CA IX is used as a marker of tumor hypoxia and as a new therapeutic target for many human carcinomas and cancers.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Human Carbonic Anhydrase IX/CA9 References
  • Loncaster JA, et al. (2001) Carbonic anhydrase (CA IX) expression, a potential new intrinsic marker of hypoxia: correlations with tumor oxygen measurements and prognosis in locally advanced carcinoma of the cervix. Cancer Res. 61(17): 6394-9.
  • Zvada J, et al. (2003) Soluble form of carbonic anhydrase IX (CA IX) in the serum and urine of renal carcinoma patients. Br J Cancer. 89(6): 1067-71.
  • Pan P, et al. (2006) Carbonic anhydrase gene expression in CA II-deficient (Car2-/-) and CA IX-deficient (Car9-/-) mice. J Physiol. 571(Pt 2): 319-27.
  • Zhou GX, et al. (2010) Quantification of carbonic anhydrase IX expression in serum and tissue of renal cell carcinoma patients using enzyme-linked immunosorbent assay: prognostic and diagnostic potentials. Urology. 75(2): 257-61.
  • Product nameProduct name
    Size / Price
    Catalog: 10107-R005-50
    List Price: 
    Price:      (You Save: )
    Size:
    50 µg
    100 µg
    Quantity:+-
    AvailabilityIn Stock
    Add to CartBulk Discount Inquiry

    Datasheet & Documentation

    All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"