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Carbonic Anhydrase IV / CA4 Antibody, Rabbit PAb, Antigen Affinity Purified

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Human CA4 Antibody Product Information
Immunogen:Recombinant Human Carbonic Anhydrase IV / CA4 protein (Catalog#10472-H08H)
Clone ID:
Ig Type:Rabbit IgG
Concentration:
Endotoxin:
Formulation:0.2 μm filtered solution in PBS with 5% trehalose
Preparation:Produced in rabbits immunized with purified, recombinant Human Carbonic Anhydrase IV / CA4 (rh Carbonic Anhydrase IV / CA4; Catalog#10472-H08H; NP_000708.1; Met 1-Lys 283). Carbonic Anhydrase IV / CA4 specific IgG was purified by Human Carbonic Anhydrase IV / CA4 affinity chromatography.
Human CA4 Antibody WB Application Image
Human CA4 Antibody IHC Application Image
Carbonic Anhydrase IV / CA4 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
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Caption:
Immunochemical staining of human CA4 in human kidney with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections). Positive staining was localized to renal tubules.
Carbonic Anhydrase IV / CA4 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
[Click to enlarge image]
Caption:
Immunochemical staining of human CA4 in human lung with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections). Positive staining was localized to pulmonary capillaries.
Human CA4 Antibody IP Application Image
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Carbonic Anhydrase IV / Car4 / CA4 Background

The carbonic anhydrases (or carbonate dehydratases) are classified as metalloenzyme for its zinc ion prosthetic group and form a family of enzymes that catalyze the rapid interconversion of carbon dioxide and water to bicarbonate and protons, a reversible reaction that takes part in maintaining acid-base balance in blood and other tissues. The carbonic anhydrasekl (CA) family consists of at least 11 enzymatically active members and a few inactive homologous proteins. Carbonic anhydrase IV (CAIV) is a membrane-associated enzyme anchored to plasma membrane surfaces by a phosphatidylinositol glycan linkage. CAIV is a high-activity isozyme in CO2 hydration comparable to that of CAII. Furthermore, CAIV is more active in HCO3- dehydration than is CAII. However, the esterase activity of CAIV is decreased 150-fold compared to CAII.

Human Carbonic Anhydrase IV / Car4 / CA4 References
  • Lehtonen J, et al. (2004) Characterization of CA XIII, a Novel Member of the Carbonic Anhydrase Isozyme Family. The Journal of Biological Chemistry. 279: 2719-27.
  • Lindskog S. (1997) Structure and mechanism of carbonic anhydrase. Pharmacology & Therapeutics. 74(1):1-20.
  • Baird TT, et al. (1997) Catalysis and Inhibition of Human Carbonic Anhydrase IV. Biochemistry. 36 (9): 2669-78.
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