Anti-Carbonic anhydrase II Antibody

Cat: 10478-R004
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Anti-Carbonic anhydrase II Antibody (Rabbit Monoclonal antibody) General Information
Product name
Anti-Carbonic anhydrase II Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human Carbonic anhydrase II
No cross-reactivity in ELISA with Human CA3 Human CA4 Human CA5A Human CA5B Human CA7 Human CA8 Human CA9 Human CA10 Human CA12 Human CA13 Human CA14
Immunogen
Recombinant Human Carbonic Anhydrase II protein (Catalog#10478-H08E)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Human Carbonic Anhydrase II (rh Carbonic Anhydrase II; Catalog#10478-H08E; NP_000058.1; Met1-Lys260).
Source
Monoclonal Rabbit IgG Clone #004
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-Carbonic anhydrase II Antibody (Rabbit Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-Carbonic anhydrase II Antibody Alternative Names
Anti-CA-II Antibody;Anti-CAC Antibody;Anti-CAII Antibody;Anti-Car2 Antibody;Anti-HEL-76 Antibody;Anti-HEL-S-282 Antibody
Carbonic anhydrase II Background Information

The carbonic anhydrases (or carbonate dehydratases) are classified as metalloenzyme for its zinc ion prosthetic group and form a family of enzymes that catalyze the rapid interconversion of carbon dioxide and water to bicarbonate and protons, a reversible reaction that takes part in maintaining acid-base balance in blood and other tissues. The carbonic anhydrasekl (CA) family consists of at least 11 enzymatically active members and a few inactive homologous proteins. Carbonic anhydrase II is one of fourteen forms of human α carbonic anhydrases. Defects in this enzyme are associated with osteopetrosis and renal tubular acidosis. Renal carbonic anhydrase allows the reabsorption of sodium ions in the proximal tubule. Carbonic anhydrase II has been shown to interact with Band 3 and Sodium-hydrogen antiporter 1.

Full Name
carbonic anhydrase II
References
  • Lehtonen J, et al. (2004) Characterization of CA XIII, a Novel Member of the Carbonic Anhydrase Isozyme Family. The Journal of Biological Chemistry. 279: 2719-27.
  • Lindskog S. (1997) Structure and mechanism of carbonic anhydrase. Pharmacology & Therapeutics. 74(1):1-20.
  • Lilias A, et al. (1972) Crystal Structure of Human Carbonic Anhydrase C. Nature new biology. 235: 131-7.
  • Li XJ, et al. (2002) Carbonic Anhydrase II Binds to and Enhances Activity of the Na+/H+ Exchanger. The Journal of Biological Chemistry. 277: 36085-91.
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    Anti-Carbonic anhydrase II Antibody Rabbit Monoclonal WB,IP 10478-R001
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