>Canonical (beta-Catenin-Dependent) Wnt Signaling
Canonical (beta-Catenin-Dependent) Wnt Signaling
Canonical (β-Catenin-Dependent) Wnt Signaling Background
Wnt pathways are involved in the control of gene expression, cell behavior, cell adhesion, and cell polarity. The Canonical (β-Catenin-Dependent) Wnt Signaling pathway is the best studied of the Wnt pathways and is highly conserved through evolution. In this pathway, Wnt signaling inhibits the degradation of β-catenin, which can regulate transcription of a number of genes. Wnt signaling is activated via ligation of Wnt proteins to their respective dimeric cell surface receptors composed of the seven transmembrane frizzled proteins and the LRP5/6. Upon ligation to their receptors, the cytoplasmic protein disheveled (Dvl) is recruited, phosphorylated and activated. Activation of Dvl induces the dissociation of GSK-3β from Axin and leads to the inhibition of GSK-3β. Next, the phosphorylation and degradation of β-catenin is inhibited as a result of the inactivation of the "destruction complex". Subsequently, stabilized β-catenin translocates into the nucleus leading to changes in different target gene expressions.
Canonical (β-Catenin-Dependent) Wnt Signaling Related Studies
- Moonl RT, et al. (2002) The Promise and Perils of Wnt Signaling Through β-Catenin. Science. 296(5573): 1644-6.
- Kuhl M, et al. (2000) The Wnt/Ca2+ pathway: a new vertebrate Wnt signaling pathway takes shape. Trends in Genetics. 16(7): 279-83.
- Cadigan KM, et al. (1997) Wnt signaling: a common theme in animal development. Genes and development. 25(14): 3286-305.