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Cancer

Cancer is a genetic disease caused by changes on genes that control critical cell functions. Normal cell proliferation is tightly regulated with a balance between the activities of proto-oncogenes and tumor suppressors. The disruption of this homeostasis leads to deregulated cell proliferation in cancer. Unlike normal cells which mature into very distinct cell types, cancer cells are less differentiated and invasive and often gain the function to avoid programmed cell death, or apoptosis, which the body uses to get rid of unneeded cells. In addition, Cancer cells are also able to evade the immune system, which normally removes damaged or abnormal cells from the body. Cancer cells will influence the microenvironment to promote angiogenesis which supply tumors with oxygen and nutrients. Metastatic tumors cause severe damage to normal body functions and result from the spread of cancer cells from the primary site to another part of the body. Cancer types are usually named for the organs or tissues where the cancers form though they can also be described by the type of cells that formed them.

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Sweden, University Researcher: Here is the data about the Ago2 protein I got from you. I am very glad to say that it is highly active, performs very good in in vitro assays and is also stable at 4C for at least for 2 weeks when tested its enzymatic activity. For sure I will recommend it to other researchers as well… , put the image on your website. It would be great to show how good product you guys have made :) US, A Biotech Company in Philadelphia: Thanks, that's great. By the way your recombinant RSVF protein works very well in biosensor experiments. It binds Synagis. UK, University researcher: I have recently bought some human BACE1 from you and was so impressed with both the price and quality of this that I had Sino Biological Inc added to the list of registered suppliers at the University . Norway, University researcher: I am very happy with the recombinant HER2 I ordered from you (under follows our mail correspondence regarding HER2), and I would like to get another two proteins from you… Germany, Pharma company: We ordered ErbB2 (No 10004-H02H) from you two month ago. We're quite satisfied with the product. Therefore I would like to know what the price for 500 g or 1 mg of ErbB2 would be. Swiss, biotech company: We have tested in our assay the FAP protein and it looks good. So we would like to order 1 mg with the offer you mentioned. I am faxing you the order right away. UK, pharma company We have assayed the material we purchased (PDB4B2), it is active and shows the expected pharmacology. In fact it is so active that we currently do not need any further material.
Sweden, University Researcher: Here is the data about the Ago2 protein I got from you. I am very glad to say that it is highly active, performs very good in in vitro assays and is also stable at 4C for at least for 2 weeks when tested its enzymatic activity. For sure I will recommend it to other researchers as well… , put the image on your website. It would be great to show how good product you guys have made :) US, A Biotech Company in Philadelphia: Thanks, that's great. By the way your recombinant RSVF protein works very well in biosensor experiments. It binds Synagis. UK, University researcher: I have recently bought some human BACE1 from you and was so impressed with both the price and quality of this that I had Sino Biological Inc added to the list of registered suppliers at the University . Norway, University researcher: I am very happy with the recombinant HER2 I ordered from you (under follows our mail correspondence regarding HER2), and I would like to get another two proteins from you… Germany, Pharma company: We ordered ErbB2 (No 10004-H02H) from you two month ago. We're quite satisfied with the product. Therefore I would like to know what the price for 500 g or 1 mg of ErbB2 would be. Swiss, biotech company: We have tested in our assay the FAP protein and it looks good. So we would like to order 1 mg with the offer you mentioned. I am faxing you the order right away. UK, pharma company We have assayed the material we purchased (PDB4B2), it is active and shows the expected pharmacology. In fact it is so active that we currently do not need any further material.

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Ang-2 B2M CD146
Referenced by: CD146 acts as a novel receptor for netrin-1 in promoting angiogenesis and vascular development
CD147
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CD20 CD22
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CD27 CD33
Referenced by: Broad and direct interaction between TLR and Siglec families of pattern recognition receptors and its regulation by Neu1
CD44 CD80
Referenced by: Blockade of the Activation of T Cells Around β-Cell by the Targeted CTLA-4 Ig at the Surface of β-Cell
CD95 CEACAM5 CTLA4
Referenced by: Fusion of CTLA-4 with HPV16 E7 and E6 Enhanced the Potency of Therapeutic HPV DNA Vaccine
CXCL12 E-Cadherin
Referenced by: Pyruvate kinase M2 facilitates colon cancer cell migration via the modulation of STAT3 signalling
EGF
Referenced by: Expression and characterization of a soluble VEGF receptor 2 protein
EGFR
Enhancing tumor-specific intracellular delivering efficiency of cell-penetrating peptide by fusion with a peptide targeting to EGFR
EpCAM
Dot-ELISA Affinity Test: An Easy, Low-Cost Method to Estimate Binding Activity of Monoclonal Antibodies
ERBB2
In vivo biotinylation and incorporation of a photo-inducible unnatural amino acid to an antibody binding domain improve site-specific labeling of antibodies
ERBB3
Inhibiting HER3-mediated tumor cell growth with affibody molecules engineered to low picomolar affinity by position-directed error-prone PCR-like diversification
ERBB4 Flt3 HGF HGFR
Anti-MET immunoPET for non-small cell lung cancer using fully human antibody fragments
HSPA1
Heat shock protein 70 is associated with replicase complex of Japanese encephalitis virus and positively regulates viral genome replication
IGFBP3
Method for Diagnosing or Determining the Prognosis of Colorectal Cancer (CRC) Using Novel Autoantigens: Gene Expression Guided Autoantigen Discovery
MMP2
Cordyceps sinensis polysaccharide CPS-2 protects human mesangial cells from PDGF-BB-induced proliferation through the PDGF/ERK and TGF-β1/Smad pathways
MMP9
Decreased plasma levels of soluble CD18 link leukocyte infiltration with disease activity in spondyloarthritis
mTOR MUC1
Lactose-Functionalized Dendrimers Arbitrate the Interaction of Galectin-3/MUC1 Mediated Cancer Cellular Aggregation
NGF
Molecular mechanism of ERK dephosphorylation by striatal-enriched protein tyrosine phosphatase
PD1
Enhancement of SIV-specific cell mediated immune responses by co-administration of soluble PD-1 and Tim-3 as molecular adjuvants in mice
PDL1
PD-L1 Expression Is Increased in a Subset of Basal Type Breast Cancer Cells
PDL2 PLTA
Comparison of protein immunoprecipitation-multiple reaction monitoring with ELISA for assay of biomarker candidates in plasma
SERPINB3
A crucial role of anti‐RPLP0 and anti‐galectin‐3 antibodies in the development of skin lesions in systemic lupus erythematosus
TGFβ
Transforming growth factor β induces expression of connective tissue growth factor in hepatic progenitor cells through Smad independent signaling
VEGF
Mimotope vaccination for epitope-specific induction of anti-VEGF antibodies
β-Catenin
Henryin, an ent-kaurane diterpenoid, inhibits Wnt signaling through interference with β-catenin/TCF4 interaction in colorectal cancer cells

Sino Biological provides a comprehensive set of reagents for studying wide broad areas of cancer research, including angiogenesis, apoptosis, cancer biomarkers, cancer stem cells, cell adhesion, signal transduction, etc.

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Cancer Related Products Index

    Cancer Related Products by Product Type

    Cancer By Species

    Cancer by Signaling Pathways

    Cancer Background

    Cancer is a class of diseases in which abnormal cells divide without control and are able to invade other tissues. Cancer cells can spread to other parts of the body through the blood and lymph systems. Normally, cell proliferation is under tight control through many mechanisms. For example, DNA damage and repair mechanisms exist in order to decrease the likelihood of genetic mutation and cell transformation. Apoptosis is needed to destroy cells that represent a threat to the integrity of the organism. In addition, the immune system is ready to recognize and destroy cancerous cells. However these error-correction methods often fail in small ways, especially in environments that make errors more likely to arise and propagate. Accumulating disruptions in these control mechanisms lead to progressive error accumulation until unregulated proliferation and cancer forming.

    Cancer References