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Calcium Signaling

Sino Biological offers a comprehensive set of tools for research on calcium signaling, including recombinant proteins, antibodies (rabbit MAbs, mouse MAbs, rabbit PAbs), ELISA kits, and gene cDNA clones.

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    Calcium Signaling by Signaling Pathways

    Calcium Signaling Background

    Calcium Signaling is important in signal transduction process, and involved in various physiological processes: cell growth, cell difference,etc. Ca2+ require the presence of specific intracellular Ca2+-binding proteins to exert their regulatory roles. A change in intracellular free calcium is a common signaling mechanism that modulates a wide array of physiological processes in most cells. Neuronal activity can lead to marked increases in the concentration of cytosolic calcium, which then functions as a second messenger that mediates a wide range of cellular responses. Ca2+ binds to calcium binding proteins (calmodulin/CaM) and stimulates the activity of a variety of enzymes, including CaM kinases and calcium-sensitive adenylate cyclases. These enzymes transduce the calcium signal and effect short-term biological responses, such as the modification of synaptic proteins and long-lasting neuronal responses that require changes in gene expression.

    Calcium Signaling References

    1. Means AR, et al. (1980) Calmodulin-an intracellular calcium receptor. J Nature. 285(5760):73-7.
    2. Ghosh A, et al. (1995) Calcium signaling in neurons: molecular mechanisms and cellular consequences. J Science. 268(5208): 239-47.
    3. Celio MR, et al. (1981) Calcium-binding protein parvalbumin as a neuronal marker. J Nature.293(5830): 300-2.