Calcium Signaling

Sino Biological offers a comprehensive set of tools for research on calcium signaling, including recombinant proteins, antibodies (rabbit MAbs, mouse MAbs, rabbit PAbs), ELISA kits, and gene cDNA clones.

Calcium Signaling Background

Calcium Signaling is important in signal transduction process, and involved in various physiological processes: cell growth, cell difference,etc. Ca²⁺ require the presence of specific intracellular Ca²⁺-binding proteins to exert their regulatory roles. A change in intracellular free calcium is a common signaling mechanism that modulates a wide array of physiological processes in most cells. Neuronal activity can lead to marked increases in the concentration of cytosolic calcium, which then functions as a second messenger that mediates a wide range of cellular responses. Ca²⁺ binds to calcium binding proteins (calmodulin/CaM) and stimulates the activity of a variety of enzymes, including CaM kinases and calcium-sensitive adenylate cyclases. These enzymes transduce the calcium signal and effect short-term biological responses, such as the modification of synaptic proteins and long-lasting neuronal responses that require changes in gene expression.

Calcium Signaling Related Studies

1. Means AR, et al. (1980) Calmodulin-an intracellular calcium receptor. J Nature. 285(5760):73-7.
2. Ghosh A, et al. (1995) Calcium signaling in neurons: molecular mechanisms and cellular consequences. J Science. 268(5208): 239-47.
3. Celio MR, et al. (1981) Calcium-binding protein parvalbumin as a neuronal marker. J Nature.293(5830): 300-2.